Treatment of visceral leishmaniasis in children with liposomal amphotericin B

被引：53

作者：

diMartino, L

Davidson, RN

Giacchino, R

Scotti, S

Raimondi, F

Castagnola, E

Tasso, L

Cascio, A

Gradoni, L

Gramiccia, M

PettoelloMantovani, M

Bryceson, ADM

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT PEDIAT, BRONX, NY 10461 USA

[2] IST GIANNINA GASLINI, DEPT PEDIAT, I-16148 GENOA, ITALY

[3] UNIV NAPLES FEDERICO II, DEPT PEDIAT, NAPLES, ITALY

[4] CHILDRENS HOSP, DEPT PEDIAT, PALERMO, ITALY

[5] IST SUPER SANITA, PARASITOL LAB, I-00161 ROME, ITALY

[6] ST MARYS HOSP, SCH MED, DEPT INFECT & TROP DIS, HARROW, MIDDX, ENGLAND

[7] HOSP TROP DIS, LONDON NW1 0PE, ENGLAND

[8] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, SCH MED, LONDON SW7 2AZ, ENGLAND

来源：

JOURNAL OF PEDIATRICS | 1997年 / 131卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(97)70165-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We used liposomal amphotericin B as first-choice treatment of visceral leishmaniasis in 106 immunocompetent children who acquired the infection in a temperate region of southern Europe (Italy) where Leishmania infantum visceral leishmaniasis is endemic. The aim of the study was to identify the minimum total dose of liposomal amphotericin B needed to cue the infection in children and reduce the period of hospitalization. We conclude that the optimal regimen in immunocompetent children with L. infantum visceral leishmaniasis to be a total dose of 18 mg/kg of liposomal amphotericin B (3 mg/kg per day for 5 days, followed by 3 mg/kg administered as an outpatient regimen on day 10).

引用

页码：271 / 277

页数：7

共 41 条

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