An Efficient Fmoc Solid-Phase Synthesis of an Amphiphile of the Neuroprotective Agent Glycyl-prolyl-glutamic Acid

被引：2

作者：

Harris, Paul W. R. ^{[1
,2
]}

Molenaar, Ger T. ^{[1
]}

Amso, Zaid ^{[1
]}

Savage, G. Paul ^{[3
]}

Brimble, Margaret A. ^{[1
,2
]}

机构：

[1] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand

[2] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland 1142, New Zealand

[3] CSIRO Mat Sci & Engn, Clayton, Vic 3168, Australia

来源：

SYNLETT | 2014年 / 25卷 / 15期

关键词：

self-assembly; peptide; Fmoc SPPS; esterification; Glypromate (R); PEPTIDE-SYNTHESIS; DELIVERY; ESTERS;

D O I：

10.1055/s-0034-1378539

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved solid-phase synthesis of the neuroprotective tripeptide, glycyl-prolyl-glutamic acid, bearing a hydrophobic tail to create an amphiphile is described. The new solid-phase synthesis was adapted to prepare several analogues bearing differing hydrophobic tails.

引用

页码：2221 / 2224

页数：4

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