Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory

被引：116

作者：

Cooper, Leroy L. ^{[1
,2
]}

Woodard, Todd ^{[1
]}

Sigurdsson, Sigurdur ^{[3
]}

van Buchem, Mark A. ^{[4
]}

Torjesen, Alyssa A. ^{[1
]}

Inker, Lesley A. ^{[5
,6
]}

Aspelund, Thor ^{[3
,7
]}

Eiriksdottir, Gudny ^{[3
]}

Harris, Tamara B. ^{[8
]}

Gudnason, Vilmundur ^{[3
,7
]}

Launer, Lenore J. ^{[8
]}

Mitchell, Gary F. ^{[1
]}

机构：

[1] Cardiovasc Engn Inc, Norwood, MA 02062 USA

[2] Brown Univ, Rhode Isl Hosp, W Alpert Med Sch, Cardiovasc Res Ctr, Providence, RI 02903 USA

[3] Iceland Heart Assoc, Kopavogur, Iceland

[4] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands

[5] Tufts Med Ctr, Div Nephrol, Boston, MA USA

[6] Tufts Med Ctr, Dept Med, Boston, MA USA

[7] Univ Iceland, Fac Med, Reykjavik, Iceland

[8] NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USA

来源：

HYPERTENSION | 2016年 / 67卷 / 01期

基金：

美国国家卫生研究院;

关键词：

cognition; dementia; hemodynamics; memory; vascular stiffness; PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; COGNITIVE DECLINE; GENE/ENVIRONMENT SUSCEPTIBILITY; BLOOD-PRESSURE; RISK-FACTORS; AGE; HEMODYNAMICS; HYPERTENSION; PULSATILITY;

D O I：

10.1161/HYPERTENSIONAHA.115.06398

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aortic stiffness is associated with cognitive decline. Here, we examined the association between carotid-femoral pulse wave velocity and cognitive function and investigated whether cerebrovascular remodeling and parenchymal small vessel disease damage mediate the relation. Analyses were based on 1820 (60% women) participants in the Age, Gene/Environment SusceptibilityReykjavik Study. Multivariable linear regression models adjusted for vascular and demographic confounders showed that higher carotid-femoral pulse wave velocity was related to lower memory score (standardized : -0.071 +/- 0.023; P=0.002). Cerebrovascular resistance and white matter hyperintensities were each associated with carotid-femoral pulse wave velocity and memory (P<0.05). Together, cerebrovascular resistance and white matter hyperintensities (total indirect effect: -0.029; 95% CI, -0.043 to -0.017) attenuated the direct relation between carotid-femoral pulse wave velocity and memory (direct effect: -0.042; 95% CI, -0.087 to 0.003; P=0.07) and explained approximate to 41% of the observed effect. Our results suggest that in older adults, associations between aortic stiffness and memory are mediated by pathways that include cerebral microvascular remodeling and microvascular parenchymal damage.

引用

页码：176 / 182

页数：7

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