Pluripotent Stem Cell-Derived Gametes: Truth and (Potential) Consequences

被引:42
作者
Mathews, Debra J. H. [1 ]
Donovan, Peter J. [2 ]
Harris, John [3 ]
Lovell-Badge, Robin [4 ]
Savulescu, Julian [5 ]
Faden, Ruth [1 ]
机构
[1] Johns Hopkins Univ, Berman Inst Bioeth, Baltimore, MD 21205 USA
[2] Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA 92697 USA
[3] Univ Manchester, Inst Sci Eth & Innovat, Manchester M13 9PL, Lancs, England
[4] Natl Inst Med Res, MRC, Div Stem Cell Biol & Dev Genet, London NW7 1AA, England
[5] Univ Oxford, Oxford Uehiro Ctr Practical Eth, Oxford OX1 1PT, England
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;
关键词
GERM-CELLS; IN-VITRO; DERIVATION;
D O I
10.1016/j.stem.2009.06.005
中图分类号
Q813 [细胞工程];
学科分类号
摘要
An emerging body of data suggests that pluripotent stem cells may be able to differentiate to form eggs and sperm. We discuss the state of the science and the potential social implications and offer recommendations for addressing some of the ethical and policy issues that would be raised by the availability of stem cell-derived gametes.
引用
收藏
页码:11 / 14
页数:4
相关论文
共 15 条
[1]   Pregnancy Outcomes After Assisted Reproductive Technology [J].
Allen, Victoria M. ;
Wilson, R. Douglas .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2006, 28 (03) :220-233
[2]   Spontaneous differentiation of germ cells from human embryonic stem cells in vitro [J].
Clark, AT ;
Bodnar, MS ;
Fox, M ;
Rodriquez, RT ;
Abeyta, MJ ;
Firpo, MT ;
Pera, RAR .
HUMAN MOLECULAR GENETICS, 2004, 13 (07) :727-739
[3]   The early days of IVF outside the UK [J].
Cohen, J ;
Trounson, A ;
Dawson, K ;
Jones, H ;
Hazekamp, J ;
Nygren, KG ;
Hamberger, L .
HUMAN REPRODUCTION UPDATE, 2005, 11 (05) :439-459
[4]   A review of ten years experience of ICSI [J].
Devroey, P ;
Van Steirteghem, A .
HUMAN REPRODUCTION UPDATE, 2004, 10 (01) :19-28
[5]   Derivation of embryonic germ cells and male gametes from embryonic stem cells [J].
Geijsen, N ;
Horoschak, M ;
Kim, K ;
Gribnau, J ;
Eggan, K ;
Daley, GQ .
NATURE, 2004, 427 (6970) :148-154
[6]   Derivation of oocytes from mouse embryonic stem cells [J].
Hübner, K ;
Fuhrmann, G ;
Christenson, LK ;
Kehler, J ;
Reinbold, R ;
De La Fuente, R ;
Wood, J ;
Strauss, JF ;
Boiani, M ;
Schöler, HR .
SCIENCE, 2003, 300 (5623) :1251-1256
[7]   Responding to fraud [J].
Kennedy, Donald .
SCIENCE, 2006, 314 (5804) :1353-1353
[8]   Science and law - Integrity in international stem cell research collaborations [J].
Mathews, Debra J. H. ;
Donovan, Peter ;
Harris, John ;
Lovell-Badge, Robin ;
Savulescu, Julian ;
Faden, Ruth .
SCIENCE, 2006, 313 (5789) :921-922
[9]   In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice [J].
Nayernia, Karim ;
Nolte, Jessica ;
Michelmann, Hans W. ;
Lee, Jae Ho ;
Rathsack, Kristina ;
Drusenheimer, Nadja ;
Dev, Arvind ;
Wulf, Gerald ;
Ehrmann, Ingrid E. ;
Elliott, David J. ;
Okpanyi, Vera ;
Zechner, Ulrich ;
Haaf, Thomas ;
Meinhardt, Andreas ;
Engel, Wolfgang .
DEVELOPMENTAL CELL, 2006, 11 (01) :125-132
[10]   Derivation of male germ cells from bone marrow stem cells [J].
Nayernia, Karim ;
Lee, Jae Ho ;
Drusenheimer, Nadja ;
Nolte, Jessica ;
Wulf, Gerald ;
Dressel, Ralf ;
Gromoll, Jorg ;
Engel, Wolfgang .
LABORATORY INVESTIGATION, 2006, 86 (07) :654-663