共 53 条
Adeno-Associated Virus-8-Mediated Intravenous Transfer of Myostatin Propeptide Leads to Systemic Functional Improvements of Slow but Not Fast Muscle
被引:21
作者:

论文数: 引用数:
h-index:
机构:

Graham, Ian R.
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Otto, Anthony
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Reading, Sch Biol Sci, Reading, Berks, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Foster, Helen
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Trollet, Capucine
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Yaworsky, Paul J.
论文数: 0 引用数: 0
h-index: 0
机构:
Wyeth Res, Clin Discovery, Collegeville, PA USA Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Walsh, Frank S.
论文数: 0 引用数: 0
h-index: 0
机构:
Wyeth Res, Clin Discovery, Collegeville, PA USA Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Bickham, Dale
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Curtin, Nancy A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Kawar, Susannah L.
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Patel, Ketan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Reading, Sch Biol Sci, Reading, Berks, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England

Dickson, George
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England
机构:
[1] Royal Holloway Univ London, Sch Biol Sci, SWAN Inst Biomed & Life Sci, Egham TW20 0EX, Surrey, England
[2] Univ Reading, Sch Biol Sci, Reading, Berks, England
[3] Wyeth Res, Clin Discovery, Collegeville, PA USA
[4] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England
关键词:
VIRUS SEROTYPE-8 VECTORS;
SKELETAL-MUSCLE;
MYOBLAST PROLIFERATION;
NEGATIVE REGULATOR;
DYSTROPHIC MUSCLE;
SELF-RENEWAL;
STEM-CELL;
GROWTH;
MICE;
GENE;
D O I:
10.1089/rej.2008.0815
中图分类号:
R592 [老年病学];
C [社会科学总论];
学科分类号:
03 ;
0303 ;
100203 ;
摘要:
Myostatin is a member of the transformating growth factor-beta (TGF-beta) superfamily of proteins and is produced almost exclusively in skeletal muscle tissue, where it is secreted and circulates as a serum protein. Myostatin acts as a negative regulator of muscle mass through the canonical SMAD2/3/4 signaling pathway. Naturally occurring myostatin mutants exhibit a 'double muscling' phenotype in which muscle mass is dramatically increased as a result of both hypertrophy and hyperplasia. Myostatin is naturally inhibited by its own propeptide; therefore, we assessed the impact of adeno-associated virus-8 (AAV8) myostatin propeptide vectors when systemically introduced in MF-1 mice. We noted a significant systemic increase in muscle mass in both slow and fast muscle phenotypes, with no evidence of hyperplasia; however, the nuclei-to-cytoplasm ratio in all myofiber types was significantly reduced. An increase in muscle mass in slow (soleus) muscle led to an increase in force output; however, an increase in fast (extensor digitorum longus [EDL]) muscle mass did not increase force output. These results suggest that the use of gene therapeutic regimens of myostatin inhibition for age-related or disease-related muscle loss may have muscle-specific effects.
引用
收藏
页码:85 / 93
页数:9
相关论文
共 53 条
[1]
Myostatin imposes reversible quiescence on embryonic muscle precursors
[J].
Amthor, H
;
Otto, A
;
Macharia, R
;
McKinnell, I
;
Patel, K
.
DEVELOPMENTAL DYNAMICS,
2006, 235 (03)
:672-680

Amthor, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

Otto, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

Macharia, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

McKinnell, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

Patel, K
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England
[2]
The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis
[J].
Amthor, H
;
Huang, RJ
;
McKinnell, I
;
Christ, B
;
Kambadur, R
;
Sharma, M
;
Patel, K
.
DEVELOPMENTAL BIOLOGY,
2002, 251 (02)
:241-257

Amthor, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

Huang, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

McKinnell, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

Christ, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

Kambadur, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

Sharma, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

论文数: 引用数:
h-index:
机构:
[3]
Lack of myostatin results in excessive muscle growth but impaired force generation
[J].
Amthor, Helge
;
Macharia, Raymond
;
Navarrete, Roberto
;
Schuelke, Markus
;
Brown, Susan C.
;
Otto, Anthony
;
Voit, Thomas
;
Muntoni, Francesco
;
Vrbova, Gerta
;
Partridge, Terence
;
Zammit, Peter
;
Bunger, Lutz
;
Patel, Ketan
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2007, 104 (06)
:1835-1840

Amthor, Helge
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Macharia, Raymond
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Navarrete, Roberto
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Schuelke, Markus
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Brown, Susan C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Otto, Anthony
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Voit, Thomas
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Muntoni, Francesco
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Vrbova, Gerta
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Partridge, Terence
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Zammit, Peter
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Bunger, Lutz
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany

Patel, Ketan
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Essen, Dept Paediat, D-45122 Essen, Germany
[4]
Mitochondria are fast Ca2+ sinks in rat extraocular muscles:: A novel regulatory influence on contractile function and metabolism
[J].
Andrade, FH
;
McMullen, CA
;
Rumbaut, RE
.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,
2005, 46 (12)
:4541-4547

Andrade, FH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kentucky, Dept Physiol, Lexington, KY USA

McMullen, CA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kentucky, Dept Physiol, Lexington, KY USA

Rumbaut, RE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kentucky, Dept Physiol, Lexington, KY USA
[5]
AAV-mediated delivery of a mutated myostatin propeptide ameliorates calpain 3 but not α-sarcoglycan deficiency
[J].
Bartoli, M.
;
Poupiot, J.
;
Vulin, A.
;
Fougerousse, F.
;
Arandel, L.
;
Daniele, N.
;
Roudaut, C.
;
Noulet, F.
;
Garcia, L.
;
Danos, O.
;
Richard, I.
.
GENE THERAPY,
2007, 14 (09)
:733-740

Bartoli, M.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Poupiot, J.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Vulin, A.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Fougerousse, F.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Arandel, L.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Daniele, N.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Roudaut, C.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Noulet, F.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Garcia, L.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Danos, O.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France

Richard, I.
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR8115, Genethon, F-91000 Evry, France CNRS, UMR8115, Genethon, F-91000 Evry, France
[6]
Functional improvement of dystrophic muscle by myostatin blockade
[J].
Bogdanovich, S
;
Krag, TOB
;
Barton, ER
;
Morris, LD
;
Whittemore, LA
;
Ahima, RS
;
Khurana, TS
.
NATURE,
2002, 420 (6914)
:418-421

Bogdanovich, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Krag, TOB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Barton, ER
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Morris, LD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Whittemore, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Ahima, RS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Khurana, TS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA
[7]
Myostatin propeptide-mediated amelioration of dystrophic pathophysiology
[J].
Bogdanovich, S
;
Perkins, KJ
;
Krag, TOB
;
Whittemore, SA
;
Khurana, TS
.
FASEB JOURNAL,
2005, 19 (06)
:543-549

Bogdanovich, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Perkins, KJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Krag, TOB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Whittemore, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

Khurana, TS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA
[8]
The formation of skeletal muscle: from somite to limb
[J].
Buckingham, M
;
Bajard, L
;
Chang, T
;
Daubas, P
;
Hadchouel, J
;
Meilhac, S
;
Montarras, D
;
Rocancourt, D
;
Relaix, F
.
JOURNAL OF ANATOMY,
2003, 202 (01)
:59-68

Buckingham, M
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

Bajard, L
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

Chang, T
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

Daubas, P
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

Hadchouel, J
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

Meilhac, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

Montarras, D
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

Rocancourt, D
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Dept Dev Biol, URA 1947, F-75015 Paris, France

论文数: 引用数:
h-index:
机构:
[9]
Skeletal muscle myostatin mRNA expression is fiber-type specific and increases dining hindlimb unloading
[J].
Carlson, CJ
;
Booth, FW
;
Gordon, SE
.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY,
1999, 277 (02)
:R601-R606

Carlson, CJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, Sch Med, Dept Integrat Biol Pharmacol & Physiol, Houston, TX 77030 USA Univ Texas, Sch Med, Dept Integrat Biol Pharmacol & Physiol, Houston, TX 77030 USA

Booth, FW
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, Sch Med, Dept Integrat Biol Pharmacol & Physiol, Houston, TX 77030 USA Univ Texas, Sch Med, Dept Integrat Biol Pharmacol & Physiol, Houston, TX 77030 USA

Gordon, SE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, Sch Med, Dept Integrat Biol Pharmacol & Physiol, Houston, TX 77030 USA Univ Texas, Sch Med, Dept Integrat Biol Pharmacol & Physiol, Houston, TX 77030 USA
[10]
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
[J].
Clop, Alex
;
Marcq, Fabienne
;
Takeda, Haruko
;
Pirottin, Dimitri
;
Tordoir, Xavier
;
Bibe, Bernard
;
Bouix, Jacques
;
Caiment, Florian
;
Elsen, Jean-Michel
;
Eychenne, Francis
;
Larzul, Catherine
;
Laville, Elisabeth
;
Meish, Francoise
;
Milenkovic, Dragan
;
Tobin, James
;
Charlier, Carole
;
Georges, Michel
.
NATURE GENETICS,
2006, 38 (07)
:813-818

Clop, Alex
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Marcq, Fabienne
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Takeda, Haruko
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Pirottin, Dimitri
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Tordoir, Xavier
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Bibe, Bernard
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Bouix, Jacques
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Caiment, Florian
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Elsen, Jean-Michel
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Eychenne, Francis
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Larzul, Catherine
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Laville, Elisabeth
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Meish, Francoise
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Milenkovic, Dragan
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Tobin, James
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Charlier, Carole
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium

Georges, Michel
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liege, Fac Vet Med, Dept Anim Prod, Unit Anim Genom, B-4000 Liege, Belgium