Numerical study of the phase separation in binary lipid membrane containing protein inclusions under stationary shear flow

被引:0
作者
Chen, Xiao-Bo [1 ]
Shi, Hui-Ji [1 ]
Niu, Li-Sha [1 ]
机构
[1] Tsinghua Univ, Dept Mech Engn, Key Lab Failure Mech, Beijing 100084, Peoples R China
关键词
Phase separation; Binary lipid membrane; Protein inclusions; Stationary shear flow; CELL-MEMBRANES; H-RAS; RAFTS; MODEL; CHOLESTEROL; MIXTURES; DYNAMICS; DOMAINS; DEFORMATION; SIMULATION;
D O I
10.1016/j.jbiomech.2008.12.008
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The phase separation of lipids is believed to be responsible for the formation of lipid rafts in biological cell membrane. In the present work, a continuum model and a particle model are constructed to study the phase separation in binary lipid membrane containing inclusions under stationary shear flow. In each model, employing the cell dynamical system (CDS) approach, the kinetic equations of the confusion-advection process are numerically solved. Snapshot figures of the phase morphology are performed to intuitively display such phase evolving process. Considering the effects from both the inclusions and the shear flow, the time growth law of the characteristic domain size is discussed. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:603 / 613
页数:11
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