Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion

被引：20

作者：

Iwakiri, Akira ^{[4
]}

Ganmyo, Hidenari ^{[4
]}

Yamamoto, Seigo ^{[4
]}

Otao, Kayoko ^{[3
]}

Mikasa, Mieko ^{[3
]}

Kizoe, Sigeko ^{[2
]}

Katayama, Kazuhiko ^{[1
]}

Wakita, Takaji ^{[1
]}

Takeda, Naokazu ^{[1
]}

Oka, Tomoichiro ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 2, Tokyo 2080011, Japan

[2] Miyazaki Prefecture Nichinan Hlth Off, Miyazaki, Japan

[3] Miyazaki Prefecture Nobeoka Hlth Off, Miyazaki, Japan

[4] Miyazaki Prefectural Inst Publ Hlth & Environm, Miyazaki, Japan

来源：

ARCHIVES OF VIROLOGY | 2009年 / 154卷 / 04期

关键词：

SAPPORO-LIKE CALICIVIRUSES; POLYMERASE-CHAIN-REACTION; NORWALK-LIKE VIRUSES; PHYLOGENETIC ANALYSIS; GENETIC DIVERSITY; GASTROENTERITIS; OUTBREAK; EPIDEMIOLOGY; PCR; ADULTS;

D O I：

10.1007/s00705-009-0358-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2-4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.

引用

页码：689 / 693

页数：5

共 22 条

[21] Acute gastroenteritis caused by G1/2 sapovirus, Taiwan, 2007
Wu, Fang-Tzy
Oka, Tomoichiro
Takeda, Naokazu
Katayama, Kazuhiko
Hansman, Grant S.
Muo, Chih-Hsin
Liang, Shy-Yuan
Hung, Ching-Hsiang
Jiang, Donald Dah-Shyong
Chang, Jui Hsin
Yang, Jyh-Yuan
Wu, Ho-Sheng
Yang, Chen-Fu
[J]. EMERGING INFECTIOUS DISEASES, 2008, 14 (07) : 1169 - 1171
[22] Detection of norovirus (GI, GII), Sapovirus and astrovirus in fecal samples using reverse transcription single-round multiplex PCR
Yan, HN
Yagyu, F
Okitsu, S
Nishio, O
Ushijima, H
[J]. JOURNAL OF VIROLOGICAL METHODS, 2003, 114 (01) : 37 - 44

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