Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion

被引：20
作者：
Iwakiri, Akira [4 ]
Ganmyo, Hidenari [4 ]
Yamamoto, Seigo [4 ]
Otao, Kayoko [3 ]
Mikasa, Mieko [3 ]
Kizoe, Sigeko [2 ]
Katayama, Kazuhiko [1 ]
Wakita, Takaji [1 ]
Takeda, Naokazu [1 ]
Oka, Tomoichiro [1 ]
机构：
[1] Natl Inst Infect Dis, Dept Virol 2, Tokyo 2080011, Japan
[2] Miyazaki Prefecture Nichinan Hlth Off, Miyazaki, Japan
[3] Miyazaki Prefecture Nobeoka Hlth Off, Miyazaki, Japan
[4] Miyazaki Prefectural Inst Publ Hlth & Environm, Miyazaki, Japan
来源：
ARCHIVES OF VIROLOGY | 2009年 / 154卷 / 04期
关键词：
SAPPORO-LIKE CALICIVIRUSES; POLYMERASE-CHAIN-REACTION; NORWALK-LIKE VIRUSES; PHYLOGENETIC ANALYSIS; GENETIC DIVERSITY; GASTROENTERITIS; OUTBREAK; EPIDEMIOLOGY; PCR; ADULTS;
D O I：
10.1007/s00705-009-0358-0
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2-4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.
引用
收藏
页码：689 / 693
页数：5
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