Self-Collected Anterior Nasal and Saliva Specimens versus Health Care Worker-Collected Nasopharyngeal Swabs for the Molecular Detection of SARS-CoV-2

被引：117

作者：

Hanson, K. E. ^{[1
,2
,5
]}

Barker, A. P. ^{[2
,5
]}

Hillyard, D. R. ^{[2
,5
]}

Gilmore, N. ^{[3
]}

Barrett, J. W. ^{[3
]}

Orlandi, R. R. ^{[4
]}

Shakir, S. M. ^{[2
,5
]}

机构：

[1] Univ Utah, Dept Med, Div Infect Dis, Sch Med, Salt Lake City, UT 84132 USA

[2] Univ Utah, Dept Pathol, Sect Clin Microbiol, Salt Lake City, UT 84132 USA

[3] Univ Utah Hosp & Clin, Salt Lake City, UT USA

[4] Univ Utah, Dept Surg, Div Otolaryngol Head & Neck Surg, Sch Med, Salt Lake City, UT USA

[5] ARUP Labs Inst Clin & Expt Pathol, Salt Lake City, UT 84108 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2020年 / 58卷 / 11期

关键词：

SARS-Cov-2; alternative specimen; anterior nasal swab; nasopharyngeal swab; saliva;

D O I：

10.1128/JCM.01824-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We prospectively compared health care worker-collected nasopharyngeal swabs (NPS) to self-collected anterior nasal swabs (ANS) and straight saliva for the diagnosis of coronavirus disease 2019 (COVID-19) in 354 patients. The percent positive agreement between NPS and ANS or saliva was 86.3% (95% confidence interval [CI], 76.7 to 92.9%) and 93.8% (95% CI, 86.0 to 97.9%), respectively. The percent negative agreement was 99.6% (95% CI, 98.0 to 100.0%) for NPS versus ANS and 97.8% (95% CI, 95.3 to 99.2%) for NPS versus saliva. More cases were detected by the use of NPS (n = 80) and saliva (n = 81) than by the use of ANS (n = 70), but no single specimen type detected all severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

引用

页数：5

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