Review of the Clinical and Biologic Aspects of Human Papillomavirus-Positive Squamous Cell Carcinomas of the Head and Neck

被引：72

作者：

Blitzer, Grace C. ^{[1
]}

Smith, Molly A. ^{[1
]}

Harris, Stephen L. ^{[3
]}

Kimple, Randall J. ^{[1
,2
]}

机构：

[1] Univ Wisconsin, Dept Human Oncol, Madison, WI 53705 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Carbone Canc Ctr, Madison, WI 53705 USA

[3] Radiat Oncol Associates, Manchester, NH USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2014年 / 88卷 / 04期

关键词：

HPV-ASSOCIATED HEAD; OROPHARYNGEAL CANCER; P16; IMMUNOHISTOCHEMISTRY; PROGNOSTIC-SIGNIFICANCE; CENTROSOME DUPLICATION; MOLECULAR MARKERS; INCREASED RISK; COPY NUMBER; PREVALENCE; E7;

D O I：

10.1016/j.ijrobp.2013.08.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human papillomavirus (HPV), a known etiology of a subset of head-and-neck squamous cell carcinomas (HNCs), causes numerous alterations in normal cellular functions. This article reviews the biology, detection, and treatment of HPV-positive HNC. The role of HPV oncoproteins in tumor development, the natural history of HPV infection, and risk factors for and prevention of transmission of oral HPV are considered. Commonly used methods for detecting HPV infection, including limitations of these methods, are discussed to aid the practicing clinician in using these tests in their clinical practice. Clinical characteristics of HPV-positive HNC, including potential explanations for the improved outcomes seen in patients with HPV-positive HNC, are assessed. Ongoing clinical trials specific for patients with HPV-positive HNC are described, and areas in need of additional research are summarized. Until the results of ongoing trials are known, treatment of HPV-positive HNC should not differ in clinical practice from treatment of similar non-HPV related cancers. (c) 2014 Elsevier Inc.

引用

页码：761 / 770

页数：10

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