A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

被引：611

作者：

Leslie, Daniel C. ^{[1
,2
,3
,4
]}

Waterhouse, Anna ^{[1
,3
,5
]}

Berthet, Julia B. ^{[1
,3
,5
]}

Valentin, Thomas M. ^{[1
,3
]}

Watters, Alexander L. ^{[1
,3
]}

Jain, Abhishek ^{[1
,3
,4
]}

Kim, Philseok ^{[1
,2
]}

Hatton, Benjamin D. ^{[1
,2
]}

Nedder, Arthur ^{[6
]}

Donovan, Kathryn ^{[6
]}

Super, Elana H. ^{[1
]}

Howell, Caitlin ^{[1
,2
]}

Johnson, Christopher P. ^{[1
,2
]}

Vu, Thy L. ^{[1
,2
]}

Bolgen, Dana E. ^{[1
]}

Rifai, Sami ^{[1
]}

Hansen, Anne R. ^{[3
,5
]}

Aizenberg, Michael ^{[1
]}

Super, Michael ^{[1
,3
,4
]}

Aizenberg, Joanna ^{[1
,2
,7
]}

Ingber, Donald E. ^{[1
,2
,3
,4
]}

机构：

[1] Harvard Univ, Wyss Inst Biologically Inspired Engn, Boston, MA 02115 USA

[2] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Boston Childrens Hosp, Vasc Biol Program, Boston, MA USA

[5] Boston Childrens Hosp, Div Newborn Med, Boston, MA USA

[6] Boston Childrens Hosp, Boston, MA USA

[7] Harvard Univ, Dept Chem & Biol Chem, Boston, MA 02115 USA

来源：

NATURE BIOTECHNOLOGY | 2014年 / 32卷 / 11期

基金：

美国国家科学基金会;

关键词：

CARDIOPULMONARY BYPASS CIRCUITS; HEPARIN; BIOCOMPATIBILITY; ANTICOAGULATION; HEMODIALYSIS; PERFORMANCE; OXYGEN; PMEA;

D O I：

10.1038/nbt.3020

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.

引用

页码：1134 / 1140

页数：7

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