Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19

被引：13

作者：

Schrul, Bianca ^{[1
]}

Schliebs, Wolfgang ^{[2
]}

机构：

[1] Saarland Univ, Ctr Mol Signaling PZMS, Med Biochem & Mol Biol, Fac Med, Kirrberger Str 100, D-66421 Homburg, Germany

[2] Ruhr Univ Bochum, Inst Biochem & Pathobiochem, Dept Syst Biochem, Fac Med, D-44780 Bochum, Germany

来源：

BIOLOGICAL CHEMISTRY | 2018年 / 399卷 / 07期

关键词：

endoplasmic reticulum; farnesylation; lipid metabolism; organelle biogenesis; PEX3; protein targeting; MEMBRANE-PROTEINS; ENDOPLASMIC-RETICULUM; STRUCTURAL BASIS; MAMMALIAN-CELLS; ER SUBDOMAINS; BIOGENESIS; IMPORT; VESICLES; RECEPTOR; MAINTENANCE;

D O I：

10.1515/hsz-2018-0125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to adapt to environmental changes, such as nutrient availability, cells have to orchestrate multiple metabolic pathways, which are catalyzed in distinct specialized organelles. Lipid droplets (LDs) and peroxisomes are both endoplasmic reticulum (ER)-derived organelles that fulfill complementary functions in lipid metabolism: Upon nutrient supply, LDs store metabolic energy in the form of neutral lipids and, when energy is needed, supply fatty acids for oxidation in peroxisomes and mitochondria. How these organelles communicate with each other for a concerted metabolic output remains a central question. Here, we summarize recent insights into the biogenesis and function of LDs and peroxisomes with emphasis on the role of PEX19 in these processes.

引用

页码：741 / 749

页数：9

共 56 条

[1] Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis [J].

Agrawal, Gaurav ;

Shang, Helen H. ;

Xia, Zhi-Jie ;

Subramani, Suresh .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (27) :11547-11560

[2] Distinct requirements for intra-ER sorting and budding of peroxisomal membrane proteins from the ER [J].

Agrawal, Gaurav ;

Fassas, Scott N. ;

Xia, Zhi-Jie ;

Subramani, Suresh .

JOURNAL OF CELL BIOLOGY, 2016, 212 (03) :335-348

[3] Cell-free sorting of peroxisomal membrane proteins from the endoplasmic reticulum [J].

Agrawal, Gaurav ;

Joshi, Saurabh ;

Subramani, Suresh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (22) :9113-9118

[4] PEX16 contributes to peroxisome maintenance by constantly trafficking PEX3 via the ER [J].

Aranovich, Alexander ;

Hua, Rong ;

Rutenberg, Andrew D. ;

Kim, Peter K. .

JOURNAL OF CELL SCIENCE, 2014, 127 (17) :3675-3686

[5] Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic [J].

Bartz, Rene ;

Li, Wen-Hong ;

Venables, Barney ;

Zehmer, John K. ;

Roth, Mary R. ;

Welti, Ruth ;

Anderson, Richard G. W. ;

Liu, Pingsheng ;

Chapman, Kent D. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :837-847

[6] Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation [J].

Bersuker, Kirill ;

Olzmann, James A. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2017, 1862 (10) :1166-1177

[7] An intimate collaboration between peroxisomes and lipid bodies [J].

Binns, Derk ;

Januszewski, Tom ;

Chen, Yue ;

Hill, Justin ;

Markin, Vladislav S. ;

Zhao, Yingming ;

Gilpin, Christopher ;

Chapman, Kent D. ;

Anderson, Richard G. W. ;

Goodman, Joel M. .

JOURNAL OF CELL BIOLOGY, 2006, 173 (05) :719-731

[8]

BLANCHETTEMACKIE EJ, 1995, J LIPID RES, V36, P1211

[9] Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins [J].

Buentzel, Judith ;

Vilardi, Fabio ;

Lotz-Havla, Amelie ;

Gaertner, Jutta ;

Thoms, Sven .

SCIENTIFIC REPORTS, 2015, 5

[10] Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis [J].

Chitraju, Chandramohan ;

Mejhert, Niklas ;

Haas, Joel T. ;

Diaz-Ramirez, L. Grisell ;

Grueter, Carrie A. ;

Imbriglio, Jason E. ;

Pinto, Shirly ;

Koliwad, Suneil K. ;

Walther, Tobias C. ;

Farese, Robert V., Jr. .

CELL METABOLISM, 2017, 26 (02) :407-+

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