Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology

被引：6

作者：

Liu, Xueying ^{[1
]}

Ran, Xiaoku ^{[1
]}

Riaz, Muhammad ^{[1
,2
]}

Kuang, Haixue ^{[3
]}

Dou, Deqiang ^{[1
]}

Cai, Decheng ^{[4
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China

[2] Shaheed Benazir Bhutto Sheringal Dir Upper, Dept Pharm, Khyber Pakhtoon Khwa 18000, Pakistan

[3] Heilongjiang Univ Chinese Med, Coll Pharm, Harbin 150040, Heilongjiang, Peoples R China

[4] Dalian Wuzhou Holy Herb Sci & Techonol Co Ltd, Dalian 116600, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 12期

关键词：

Tagetes patula L; chronic nonbacterial prostatitis; metabolomics; energy metabolism; network pharmacology; SERUM URIC-ACID; INDUCED INFLAMMATION; METABOLISM;

D O I：

10.3390/molecules24122266

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The major objective of this study was to investigate the anti-chronic nonbacterial prostatitis (CNP) mechanism of T. patula by metabolomics and network pharmacology. The study demonstrated that the flavonoids and polysaccharides of T. patula could alleviate prostatitis by improving the level of DHT, reducing the secretion of PSA and TNF-alpha. Besides, both could enhance Na+/K+-ATPase activity, decrease the O-2 consumption, CO2 production, heat production, energy expenditure of rats and promote respiratory exchange ratio of rats. Up to 28 potential biomarkers and 8 key metabolic pathways related to the treatment of CNP were elucidated by the metabolomics analysis, including phenylalanine metabolism, taurine and hypotaurine metabolism, tryptophan metabolism etc. Network pharmacology prediction also reflected the potential mechanism was associated with tryptophan metabolism and energy pathway. Generally, the potential anti-CNP mechanism of flavonoids and polysaccharides of T. patula might be through reducing the expression of inflammation factors, adjusting the level of hormone and regulating the amino acid metabolism, energy metabolism and glucose and lipid metabolism.

引用

页数：15

共 22 条

[1] Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents [J].

Alemzadeh, Ramin ;

Kichler, Jessica .

METABOLIC SYNDROME AND RELATED DISORDERS, 2016, 14 (03) :167-174

[2]

Bano H., 2002, J PHARM SCI, V15, P1

[3] Effect of increasing dietary threonine intakes on amino acid metabolism of the central nervous system and peripheral tissues in growing rats [J].

Boehm, G ;

Cervantes, H ;

Georgi, G ;

Jelinek, J ;

Sawatzki, G ;

Wermuth, B ;

Colombo, JP .

PEDIATRIC RESEARCH, 1998, 44 (06) :900-906

[4] Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells [J].

Costello, LC ;

Franklin, RB .

HORMONE AND METABOLIC RESEARCH, 2002, 34 (08) :417-424

[5] Inverse Molecular Docking as a Novel Approach to Study Anticarcinogenic and Anti-Neuroinflammatory Effects of Curcumin [J].

Furlan, Veronika ;

Konc, Janez ;

Bren, Urban .

MOLECULES, 2018, 23 (12)

[6]

Jie N., 2013, CHINESE HLTH FOOD, P12

[7]

Jin G., 2006, BIOCHEMISTRY-US, P156

[8] Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model [J].

Kasahara, Y ;

Yasukawa, K ;

Kitanaka, S ;

Khan, MT ;

Evans, FJ .

PHYTOTHERAPY RESEARCH, 2002, 16 (03) :217-222

[9]

Li XY, 2015, PROG BIOCHEM BIOPHYS, V42, P810, DOI 10.16476/j.pibb.2015.0115

[10]

Liu J., 2003, CHINA FOOD ADDICT, P52

← 1 2 3 →