Task-specific ionic liquid catalyzed synthesis of novel naphthoquinone-urazole hybrids and evaluation of their antioxidant and in vitro anticancer activity

被引：26
|
作者：
Saluj, Pooja [1 ]
Khurana, Jitender M. [1 ]
Nikhil, Kumar [2 ]
Roy, Partha [2 ]
机构：
[1] Univ Delhi, Dept Chem, Delhi 110007, India
[2] Indian Inst Technol Roorkee, Dept Biotechnol, Roorkee 247667, UK, India
来源：
RSC ADVANCES | 2014年 / 4卷 / 65期
关键词：
STRUCTURAL-CHARACTERIZATION; PLUMBAGIN; CYTOTOXICITY; MOLECULES; GROWTH; ASSAY;
D O I：
10.1039/c4ra02917h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have reported the synthesis of naphthoquinone-urazole hybrids via one pot condensation of 2-hydroxynapthalene-1,4-dione, aldehydes and 4-phenylurazole using task specific ionic liquid (bmim [HSO4]). All newly synthesized compounds were screened for in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and anticancer activity against human breast (T47D), colon (HCT-15), lung (NCI-H522), liver (HepG-2) and ovary (PA-1) cancer cell lines. All the naphthoquinone-urazole hybrids showed high DPPH radical scavenging activity, comparable to the standard BHT. Compounds IVf, IVh, IVi and IVj exhibited very good anticancer activity.
引用
收藏
页码：34594 / 34603
页数：10
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