Leukemia stem cells: Old concepts and new perspectives

被引：7
作者：
Mariani, Samanta A.
Calabretta, Bruno [1 ]
机构：
[1] Thomas Jefferson Univ, Dept Canc Biol, Philadelphia, PA 19107 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2014年 / 39卷
关键词：
Stem cell; Leukemia; Oncogene; Therapy; CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; COMPLETE MOLECULAR REMISSION; IMMUNE-DEFICIENT MICE; RECEPTOR-ALPHA CHAIN; BCR-ABL; BONE-MARROW; IMATINIB; PERSISTENCE; TRANSPLANTATION;
D O I：
10.1016/j.mam.2013.06.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Myeloid leukemias are heterogeneous malignancies in morphology, immunophenotype, genetic and epigenetic alterations, and response to therapy. This heterogeneity is thought to depend on the accumulation of secondary Mutations enhancing proliferation/survival and/or blocking differentiation in a small subset of leukemia-initiating cells capable of self-renewal. This model of clonal evolution is based on xenotransplantation studies demonstrating that leukemia can be initiated and maintained in immunodeficient mice by a small subset of purified leukemic cells immunophenotypically similar to normal hematopoietic stem cells and is known as the leukemia stem cell model. Since its original formulation, many studies have validated the main conclusion of this model. However, recent data from xenotransplantation studies in more severely immunodeficient mice suggest that imunophenotype and behavior of leukemic stem cells is more heterogeneous and "plastic" than originally thought. We will discuss here the evolution of the leukemia stem cell model and its impact for the therapy of patients with myeloid malignancies. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：102 / 109
页数：8
相关论文
共 61 条
[1]   Leukemia stem cells in 2010: Current understanding and future directions [J].
Becker, Michael W. ;
Jordan, Craig T. .
BLOOD REVIEWS, 2011, 25 (02) :75-81
[2]   Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells [J].
Bellodi, Cristian ;
Lidonnici, Maria Rosa ;
Hamilton, Ashley ;
Helgason, G. Vignir ;
Soliera, Angela Rachele ;
Ronchetti, Mattia ;
Galavotti, Sara ;
Young, Kenneth W. ;
Selmi, Tommaso ;
Yacobi, Rinat ;
Van Etten, Richard A. ;
Donato, Nick ;
Hunter, Ann ;
Dinsdale, David ;
Tirro, Elena ;
Vigneri, Paolo ;
Nicotera, Pierluigi ;
Dyer, Martin J. ;
Holyoake, Tessa ;
Salomoni, Paolo ;
Calabretta, Bruno .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (05) :1109-1123
[3]   Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment [J].
Bhatia, R ;
Holtz, M ;
Niu, N ;
Gray, R ;
Snyder, DS ;
Sawyers, CL ;
Arber, DA ;
Slovak, ML ;
Forman, SJ .
BLOOD, 2003, 101 (12) :4701-4707
[4]   Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].
Bonnet, D ;
Dick, JE .
NATURE MEDICINE, 1997, 3 (07) :730-737
[5]   The significance of early, major and stable molecular responses in chronic myeloid leukemia in the imatinib era [J].
Breccia, Massimo ;
Alimena, Giuliana .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2011, 79 (02) :135-143
[6]   The biology of CML blast crisis [J].
Calabretta, B ;
Perrotti, D .
BLOOD, 2004, 103 (11) :4010-4022
[7]   Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia [J].
Castor, A ;
Nilsson, L ;
Åstrand-Grundström, I ;
Buitenhuis, M ;
Ramirez, C ;
Anderson, K ;
Strömbeck, B ;
Garwicz, S ;
Békássy, AN ;
Schmiegelow, K ;
Lausen, B ;
Hokland, P ;
Lehmann, S ;
Juliusson, G ;
Johansson, B ;
Jacobsen, SEW .
NATURE MEDICINE, 2005, 11 (06) :630-637
[8]   Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease [J].
Chomel, Jean-Claude ;
Bonnet, Marie-Laure ;
Sorel, Nathalie ;
Bertrand, Angelina ;
Meunier, Marie-Claude ;
Fichelson, Serge ;
Melkus, Michael ;
Bennaceur-Griscelli, Annelise ;
Guilhot, Francois ;
Turhan, Ali G. .
BLOOD, 2011, 118 (13) :3657-3660
[9]   Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment [J].
Chu, Su ;
McDonald, Tinisha ;
Lin, Allen ;
Chakraborty, Sujata ;
Huang, Qin ;
Snyder, David S. ;
Bhatia, Ravi .
BLOOD, 2011, 118 (20) :5565-5572
[10]   Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity [J].
Corbin, Amie S. ;
Agarwal, Anupriya ;
Loriaux, Marc ;
Cortes, Jorge ;
Deininger, Michael W. ;
Druker, Brian J. .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (01) :396-409
1234567