Potential Stages for Prostate Cancer Prevention with Selenium: Implications for Cancer Survivors

被引：37

作者：

Facompre, Nicole ^{[1
]}

El-Bayoumy, Karam ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Penn State Hershey Canc Inst, Dept Biochem & Mol Biol, Hershey, PA 17033 USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 07期

关键词：

SUPPLEMENTATION; CHEMOPREVENTION; TRIAL; RISK;

D O I：

10.1158/0008-5472.CAN-08-4359

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The lack of treatment for "worried well" patients with high-grade prostatic intraepithelial neoplasia combined with issues of recurrence and hormone resistance in pros a e cancer survivors remains a major public health obstacle. The long latency of prostate cancer development provides an ample opportunity to intervene with mechanistically based chemopreventive agents at various stages of disease progression. Our rationale for selenium intervention is based on current mechanistic knowledge derived solely from preclinical investigations. Clearly, there is sufficient scientific support for its entry into current clinical trials, the outcome of which will be highly valuable in assessing whether selenium can be recommended for cancer survivors. [Cancer Res 2009;69(7):2699-703]

引用

页码：2699 / 2703

页数：5

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