Epidemiology, Prognosis, and Risk Factors in Mastocytosis

被引：130

作者：

Brockow, Knut ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Dermatol & Allergy Biederstein, D-80802 Munich, Germany

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2014年 / 34卷 / 02期

关键词：

Mastocytosis; Mast cell activity syndrome; Monoclonal mast cell activation syndrome; Epidemiology; Prognosis; Risk factors; INDOLENT SYSTEMIC MASTOCYTOSIS; MAST-CELL DISEASE; HYMENOPTERA VENOM ALLERGY; D816V MUTATION BURDEN; BONE-MARROW PATHOLOGY; URTICARIA PIGMENTOSA; TRYPTASE LEVELS; CLINICAL-MANIFESTATIONS; CUTANEOUS MASTOCYTOSIS; ANAPHYLACTIC REACTIONS;

D O I：

10.1016/j.iac.2014.01.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This article updates current knowledge about epidemiology, prognosis, and risk factors for major complications in mastocytosis. A prevalence of mastocytosis of 1 in 10000 inhabitants has been reported, but under-diagnosis is assumed. The prognosis for cutaneous and indolent systemic mastocytosis is excellent. For more advanced forms of disease, prognostic parameters have been identified. A high extent of skin involvement, increased basal serum tryptase values, and extensive blistering are risk factors for severe mast cell activation episodes in children, whereas these associations seem to be less strong or nonexistent for anaphylaxis and osteoporosis in adult patients with indolent systemic mastocytosis.

引用

页码：283 / +

页数：14

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