Complement Factors in COVID-19 Therapeutics and Vaccines

被引：32
作者：
Kurtovic, Liriye [1 ,2 ]
Beeson, James G. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Burnet Inst, Melbourne, Vic, Australia
[2] Monash Univ, Dept Immunol & Pathol, Melbourne, Vic, Australia
[3] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia
[4] Monash Univ, Dept Microbiol, Melbourne, Vic, Australia
[5] Univ Melbourne, Dept Med, Parkville, Vic, Australia
来源：
TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 02期
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
MONOCLONAL-ANTIBODIES; PROTECTION; VIRUS; NEUTRALIZATION; ACTIVATION; MALARIA; PATHOGENESIS; SPOROZOITES; SERUM;
D O I：
10.1016/j.it.2020.12.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Complement is integral to a healthy functioning immune system and orchestrates various innate and adaptive responses against viruses and other pathogens. Despite its importance, the potential beneficial role of complement in immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been overshadowed by reports of extensive complement activation in severe coronavirus disease 2019 (COVID-19) patients. Here, we hypothesize that complement may also have a protective role and could function to enhance virus neutralization by antibodies, promote virus phagocytosis by immune cells, and lysis of virus. These functions might be exploited in the development of effective therapeutics and vaccines against SARS-CoV-2.
引用
收藏
页码：94 / 103
页数：10
相关论文
共 78 条
[41]   Complement Protein C1q Reduces the Stoichiometric Threshold for Antibody-Mediated Neutralization of West Nile Virus [J].
Mehlhop, Erin ;
Nelson, Steevenson ;
Jost, Christiane A. ;
Gorlatov, Sergey ;
Johnson, Syd ;
Fremont, Daved H. ;
Diamond, Michael S. ;
Pierson, Theodore C. .
CELL HOST & MICROBE, 2009, 6 (04) :381-391
[42]   Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics [J].
Mellors, Jack ;
Tipton, Tom ;
Longet, Stephanie ;
Carroll, Miles .
FRONTIERS IN IMMUNOLOGY, 2020, 11
[43]   Complement system part II: role in immunity [J].
Merle, Nicolas S. ;
Noe, Remi ;
Halbwachs-Mecarelli, Lise ;
Fremeaux-Bacchi, Veronique ;
Roumenina, Lubka T. .
FRONTIERS IN IMMUNOLOGY, 2015, 6
[44]   Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein [J].
Meyer, K ;
Basu, A ;
Przysiecki, CT ;
Lagging, LM ;
Di Bisceglie, AM ;
Conley, AJ ;
Ray, R .
JOURNAL OF VIROLOGY, 2002, 76 (05) :2150-2158
[45]   Autoantibody-mediated complement activation on platelets is a common finding in patients with immune thrombocytopenic purpura (ITP) [J].
Najaoui, Abderrahim ;
Bakchoul, Tamam ;
Stoy, Johanna ;
Bein, Gregor ;
Rummel, Mathias J. ;
Santoso, Sentot ;
Sachs, Ulrich J. .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2012, 88 (02) :167-174
[46]   Investigating the spectrum of dermatologic manifestations inCOVID-19 infection in severely ill patients: A series of four cases [J].
Occidental, Michael ;
Flaifel, Abdallah ;
Lin, Lawrence H. ;
Guzzetta, Melissa ;
Thomas, Kristen ;
Jour, George .
JOURNAL OF CUTANEOUS PATHOLOGY, 2021, 48 (01) :110-115
[47]   CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering [J].
Oostindie, Simone C. ;
van der Horst, Hilma J. ;
Lindorfer, Margaret A. ;
Cook, Erika M. ;
Tupitza, Jillian C. ;
Zent, Clive S. ;
Burack, Richard ;
VanDerMeid, Karl R. ;
Strumane, Kristin ;
Chamuleau, Martine E. D. ;
Mutis, Tuna ;
de Jong, Rob N. ;
Schuurman, Janine ;
Breij, Esther C. W. ;
Beurskens, Frank J. ;
Parren, Paul W. H., I ;
Taylor, Ronald P. .
HAEMATOLOGICA, 2019, 104 (09) :1841-1852
[48]   Serum proteomic fingerprints of adult patients with severe acute respiratory syndrome [J].
Pang, RTK ;
Poon, TCW ;
Chan, KCA ;
Lee, NLS ;
Chiu, RWK ;
Tong, YK ;
Wong, RMY ;
Chim, SSC ;
Ngai, SM ;
Sung, JJY ;
Lo, YMD .
CLINICAL CHEMISTRY, 2006, 52 (03) :421-429
[49]   Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 [J].
Perico, Luca ;
Benigni, Ariela ;
Casiraghi, Federica ;
Ng, Lisa F. P. ;
Renia, Laurent ;
Remuzzi, Giuseppe .
NATURE REVIEWS NEPHROLOGY, 2021, 17 (01) :46-64
[50]   COVID-19 infection in patients on anti-complement therapy: The Leeds National Paroxysmal Nocturnal Haemoglobinuria service experience [J].
Pike, Alexandra ;
Muus, Petra ;
Munir, Tahla ;
Mitchell, Lindsay ;
Arnold, Louise ;
Riley, Kathryn ;
Houghton, Nicola ;
Forrest, Briony ;
Gachev, Jeanifer ;
Hillmen, Peter ;
Griffin, Morag .
BRITISH JOURNAL OF HAEMATOLOGY, 2020, 191 (01) :E1-E4
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