Complement Factors in COVID-19 Therapeutics and Vaccines

被引：32

作者：

Kurtovic, Liriye ^{[1
,2
]}

Beeson, James G. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Burnet Inst, Melbourne, Vic, Australia

[2] Monash Univ, Dept Immunol & Pathol, Melbourne, Vic, Australia

[3] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia

[4] Monash Univ, Dept Microbiol, Melbourne, Vic, Australia

[5] Univ Melbourne, Dept Med, Parkville, Vic, Australia

来源：

TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 02期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

MONOCLONAL-ANTIBODIES; PROTECTION; VIRUS; NEUTRALIZATION; ACTIVATION; MALARIA; PATHOGENESIS; SPOROZOITES; SERUM;

D O I：

10.1016/j.it.2020.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complement is integral to a healthy functioning immune system and orchestrates various innate and adaptive responses against viruses and other pathogens. Despite its importance, the potential beneficial role of complement in immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been overshadowed by reports of extensive complement activation in severe coronavirus disease 2019 (COVID-19) patients. Here, we hypothesize that complement may also have a protective role and could function to enhance virus neutralization by antibodies, promote virus phagocytosis by immune cells, and lysis of virus. These functions might be exploited in the development of effective therapeutics and vaccines against SARS-CoV-2.

引用

页码：94 / 103

页数：10

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