miR-215 suppresses proliferation and migration of non-small cell lung cancer cells

被引：29
|
作者：
Cai, Xiaopan [1 ]
Peng, Dongyu [1 ]
Wei, Haifeng [1 ]
Yang, Xinghai [1 ]
Huang, Quan [1 ]
Lin, Zaijun [1 ]
Xu, Wei [1 ]
Qian, Ming [1 ]
Yang, Cheng [1 ]
Liu, Tielong [1 ]
Yan, Wangjun [1 ]
Zhao, Jian [1 ]
机构：
[1] Second Mil Med Univ, Changzheng Hosp, Dept Bone Tumor Surg, 415 Fengyang Rd, Shanghai 200003, Peoples R China
来源：
ONCOLOGY LETTERS | 2017年 / 13卷 / 04期
关键词：
non-small cell lung cancer; migration; microRNA; lung cancer; miR-215; TUMOR-SUPPRESSOR; POOR-PROGNOSIS; COLON-CANCER; RISK-FACTORS; EPIDEMIOLOGY; DIAGNOSIS; MICRORNA; METASTASIS; PATHWAY; MARKER;
D O I：
10.3892/ol.2017.5692
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The expression of microRNA-215 (miR-215) in non-small cell lung cancer (NSCLC) tissues and the effects of miR-215 on the proliferation and migration of NSCLC cells were investigated. qRT-PCR was used to detect the expression of miR-215 in NSCLC tissues and paired normal tumor-adjacent lung tissues; MTT assay, transwell assay and soft-agar assay were used in vitro to evaluate the role of miR-215 on proliferation, migration and cell clonality on NSCLC cells, after transfecting miR-215 mimics to NSCLC cell line A549 or miR-215 to H1299. miR-215 was significantly decreased in NSCLC tissues compared to the paired normal tissues; Overexpression of miR-215 in A549 cells resulted in reduction of the cell proliferation, migration and cell clonality, while downregulation of miR-215 in H1299 cells could promote cell proliferation, migration and clonality. In conclusion, miR-215 was downregulated in NSCLC tissues and may play a key role in the development of NSCLC.
引用
收藏
页码：2349 / 2353
页数：5
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