One-Pot Highly Regioselective Synthesis of Indole-Fused Pyridazino[4,5-b][1,4]benzoxazepin-4(3H)-ones by a Smiles Rearrangement

被引：8

作者：

Jiang, Xiaolei ^{[1
]}

Hu, Fangdong ^{[1
]}

机构：

[1] Linyi Univ, Sch Chem & Chem Engn, Linyi 276005, Shandong, Peoples R China

来源：

SYNLETT | 2018年 / 29卷 / 09期

关键词：

indoles; indolopyridazinobenzoxazepinanes; regioselectivity; polycyclic heterocycles; Smiles rearrangement; DIBENZOXAZEPINONES; CONSTRUCTION;

D O I：

10.1055/s-0037-1609338

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and convenient synthesis of indole-fused pyridazino[4,5-b][1,4]benzoxazepin-4(3H)-ones is described. A range of 2-(1Hindol-2-yl)phenols and 4,5-dichloropyridazln-3-ones are compatible with this reaction. A Smiles rearrangement is proposed as a key step in the highly regioselective construction of the products. The easy availability of the starting materials makes this an appealing method in organic synthesis.

引用

页码：1207 / 1210

页数：4

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