Kill the messenger: bacterial antisense RNA promotes mRNA decay

被引：26

作者：

Wagner, E. Gerhart H. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Cell & Mol Biol, Microbiol Program, Uppsala, Sweden

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 08期

关键词：

SM-LIKE PROTEIN; ESCHERICHIA-COLI; NONCODING RNAS; DEGRADATION; REGULATOR; TRANSLATION; COMPLEXES; ELEMENTS; TARGETS; BINDING;

D O I：

10.1038/nsmb0809-804

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial antisense RNAs target translation initiation regions (TIRs) to compete with ribosome binding, thus repressing translation and-secondarily-causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within the coding region, far downstream of the TIR.

引用

页码：804 / 806

页数：3

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