IRGM1, a guardian of mitochondrial DAMP-mediated autoinflammation

被引：6

作者：

Kaufman, Brett A. ^{[1
]}

Mora, Ana L. ^{[2
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med, Ctr Metab & Mitochondrial Med,Div Cardiol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Div Pulm Allergy & Crit Care Med, Aging Inst, Pittsburgh, PA 15260 USA

来源：

NATURE IMMUNOLOGY | 2021年 / 22卷 / 03期

关键词：

D O I：

10.1038/s41590-021-00877-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IRGM1 is recognized as a master regulator of type I interferon responses against pathogens, while also protecting against autoimmune diseases. It has now been shown that IRGM1 controls autoinflammatory responses by modulating mitophagy flux.

引用

页码：272 / 273

页数：2

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