Alterations in Ca2+-ATPase activity and calcium binding protein regucalcin mRNA expression in the kidney cortex of rats with saline ingestion

被引:12
作者
Shinya, N [1 ]
Yamaguchi, M [1 ]
机构
[1] UNIV SHIZUOKA,GRAD SCH NUTR SCI,LAB ENDOCRINOL & MOL METAB,SHIZUOKA 422,JAPAN
关键词
calcium metabolism; Ca2+-ATPase; regucalcin; kidney cortex; saline ingestion;
D O I
10.1023/A:1006821928397
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The alteration in calcium metabolism in rats ingested with saline was investigated. Rats were freely given saline as drinking water for 2 and 7 days. Calcium concentration in the serum was significantly elevated by saline ingestion for 2 and 7 days, while serum inorganic phosphorus concentration was not altered. Serum urea nitrogen concentration was significantly increased by saline ingestion for 7 days. Calcium content in the femoral-diaphyseal and metaphyseal tissues was not altered by saline ingestion for 7 days. Calcium content in the kidney cortex was significantly elevated by saline ingestion for 7 days. Ca2+-ATPase activity in the basolsateral membranes of kidney cortex was clearly increased by saline ingestion for 2 and 7 days. The enzyme activity was not altered by the addition of sodium chloride (10(-3) and 10(-2) M), parathyroid hormone (10(-7) and 10(-6) M), and calcitonin (3 x 10(-8) and 3 x 10(-7) M) in the enzyme reaction mixture. A calcium-binding protein regucalcin mRNA expression in the kidney cortex was markedly suppressed by saline ingestion for 7 days, although such a suppression was not seen for 2 days. These results suggest that saline ingestion causes the disturbance of calcium transport system in the kidney cortex of rats, and that the renal disorder may induce hypercalcemia.
引用
收藏
页码:17 / 22
页数:6
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