The complex role of genetic background in shaping the effects of spontaneous and induced mutations

被引：7
作者：
Goldstein, Ilan [1 ]
Ehrenreich, Ian M. [1 ]
机构：
[1] Univ Southern Calif, Dept Biol Sci, Mol & Computat Biol Sect, Los Angeles, CA 90089 USA
来源：
YEAST | 2021年 / 38卷 / 03期
基金：
美国国家卫生研究院;
关键词：
NATURAL VARIATION; MOLECULAR-BASIS; MODIFIER GENES; EPISTASIS; PHENOTYPE; HSP90; ARCHITECTURE; EXPRESSION; GENOTYPE; RNA;
D O I：
10.1002/yea.3530
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Spontaneous and induced mutations frequently show different phenotypic effects across genetically distinct individuals. It is generally appreciated that these background effects mainly result from genetic interactions between the mutations and segregating loci. However, the architectures and molecular bases of these genetic interactions are not well understood. Recent work in a number of model organisms has tried to advance knowledge of background effects both by using large-scale screens to find mutations that exhibit this phenomenon and by identifying the specific loci that are involved. Here, we review this body of research, emphasizing in particular the insights it provides into both the prevalence of background effects across different mutations and the mechanisms that cause these background effects.
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收藏
页码：187 / 196
页数：10
相关论文
共 87 条
[1]   New insights into the generation and role of de novo mutations in health and disease [J].
Acuna-Hidalgo, Rocio ;
Veltman, Joris A. ;
Hoischen, Alexander .
GENOME BIOLOGY, 2016, 17
[2]   Network biology:: Understanding the cell's functional organization [J].
Barabási, AL ;
Oltvai, ZN .
NATURE REVIEWS GENETICS, 2004, 5 (02) :101-U15
[3]   Evolutionary capacitance as a general feature of complex gene networks [J].
Bergman, A ;
Siegal, ML .
NATURE, 2003, 424 (6948) :549-552
[4]   Genetic interactions contribute less than additive effects to quantitative trait variation in yeast [J].
Bloom, Joshua S. ;
Kotenko, Iulia ;
Sadhu, Meru J. ;
Treusch, Sebastian ;
Albert, Frank W. ;
Kruglyak, Leonid .
NATURE COMMUNICATIONS, 2015, 6
[5]   Finding the sources of missing heritability in a yeast cross [J].
Bloom, Joshua S. ;
Ehrenreich, Ian M. ;
Loo, Wesley T. ;
Thuy-Lan Vo Lite ;
Kruglyak, Leonid .
NATURE, 2013, 494 (7436) :234-237
[6]  
Bogaert J., 2014, ANN GASTROENTEROLOGY
[7]  
Boone C., 2007, NATURE REV GENETICS
[8]   Epistasis:: too often neglected in complex trait studies? [J].
Carlborg, Ö ;
Haley, CS .
NATURE REVIEWS GENETICS, 2004, 5 (08) :618-U4
[9]   How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects [J].
Chandler, Christopher H. ;
Chari, Sudarshan ;
Kowalski, Alycia ;
Choi, Lin ;
Tack, David ;
DeNieu, Michael ;
Pitchers, William ;
Sonnenschein, Anne ;
Marvin, Leslie ;
Hummel, Kristen ;
Marier, Christian ;
Victory, Andrew ;
Porter, Cody ;
Mammel, Anna ;
Holms, Julie ;
Sivaratnam, Gayatri ;
Dworkin, Ian .
PLOS GENETICS, 2017, 13 (11)
[10]   Causes and Consequences of Genetic Background Effects Illuminated by Integrative Genomic Analysis [J].
Chandler, Christopher H. ;
Chari, Sudarshan ;
Tack, David ;
Dworkin, Ian .
GENETICS, 2014, 196 (04) :1321-+
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