Synthesis and characterization of biocompatible magnetic glyconanoparticles

被引：30

作者：

Kekkonen, Viktoria ^{[1
]}

Lafreniere, Nelson ^{[1
]}

Ebara, Mitsuhiro ^{[2
]}

Saito, Atsuhiro ^{[2
]}

Sawa, Yoshiki ^{[2
]}

Narain, Ravin ^{[1
]}

机构：

[1] Laurentian Univ, Dept Chem & Biochem, Biomol Sci Program, Sudbury, ON P3E 2C6, Canada

[2] Osaka Univ Hosp, Med Ctr Translat Res, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期

关键词：

Glyconanoparticle; Iron oxide; Biomedical application; Cell viability; Co-precipitation method; NANOPARTICLES; SHELL; ACID;

D O I：

10.1016/j.jmmm.2009.02.045

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Magnetic glyconanoparticles were synthesized via the co-precipitation method. Iron (II) and iron (III) chloride were co-precipitated out of solution by the addition of ammonium hydroxide in an aqueous solution containing carbohydrate stabilizers such as D-gluconic acid, lactobionic acid and Ficoll at 75-80 degrees C. Stable magnetic glyconanoparticles were formed in a simple and direct process. Dynamic light scattering and transmission electron microscopy were used to characterize the surface-coated magnetic nanoparticles. In vitro cell viability studies of the glyconanoparticles were conducted with the mouse fibroblast cell lines. The magnetic glyconanoparticles revealed to be non-toxic at a concentration as high as 0.1 mg/mL. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1393 / 1396

页数：4

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