A Human PBPK/PD Model to Assess Arsenic Exposure Risk Through Farmed Tilapia Consumption

被引：5

作者：

Ling, M. -P. ^{[1
]}

Liao, C. -M. ^{[2
]}

机构：

[1] China Med Univ, Dept Hlth Risk Management, Taichung 40402, Taiwan

[2] Natl Taiwan Univ, Dept Bioenvironm Syst Engn, Taipei 10617, Taiwan

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2009年 / 83卷 / 01期

关键词：

Arsenic; PBPK/PD; Risk analysis; Consumption advice; PHARMACOKINETIC MODEL; BLACKFOOT-DISEASE; TAIWAN;

D O I：

10.1007/s00128-009-9764-y

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The purpose of this study was to develop a biologically based risk assessment model for human health through consumption of arsenic (As) contaminated farmed tilapia (Oreochromis mossambicus) from blackfoot disease (BFD)-endemic area in Taiwan for estimating the consumption advice. We linked a physiologically based pharmacokinetic (PBPK) and a pharmacodynamic (PD) model to account for the exposure and dose-response profiles of As in human. Risk analysis indicates that consumption of farmed tilapia poses no significant threat from As-induced lung and bladder cancers. The predicted risk-based median consumption advice was no more than 5-17 meals month(-1) (or 2-6 g day(-1)).

引用

页码：108 / 114

页数：7

共 18 条

[1]

[Anonymous], 2000, RISK ASSESSMENT FISH, V2

[2]

[Anonymous], 1998, Federal Register, V63, P26846

[3]

ATSDR (Agency for Toxic Substances & Disease Registry), 2000, TOX PROF ARS

[4]

*DEP STAT, 2006, YEARL STAT POP

[5]

Department of Health, 2006, HLTH NAT HLTH INS AN

[6]

*FISH ADM, 2006, TAIW AR PROC FISH PR

[7] Arsenic species contents at aquaculture farm and in farmed mouthbreeder (Oreochromis mossambicus) in blackfoot disease hyperendemic areas [J].

Huang, YK ;

Lin, KH ;

Chen, HW ;

Chang, CC ;

Liu, CW ;

Yang, MH ;

Hsueh, YM .

FOOD AND CHEMICAL TOXICOLOGY, 2003, 41 (11) :1491-1500

[8] A pharmacokinetic analysis of interspecies extrapolation in dioxin risk assessment [J].

Lawrence, GS ;

Gobas, FAPC .

CHEMOSPHERE, 1997, 35 (03) :427-452

[9] A physiologically based biokinetic model for cesium in the human body [J].

Leggett, RW ;

Williams, LR ;

Melo, DR ;

Lipsztein, JL .

SCIENCE OF THE TOTAL ENVIRONMENT, 2003, 317 (1-3) :235-255

[10] A PBTK/TD Modeling-Based Approach Can Assess Arsenic Bioaccumulation in Farmed Tilapia (Oreochromis mossambicus) and Human Health Risks [J].

Ling, Min-Pei ;

Liao, Chung-Min ;

Tsai, Jeng-Wei ;

Chen, Bo-Ching .

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, 2005, 1 (01) :40-54

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