Characteristics of Mesenchymal Stromal Cells Isolated from Patients with Breast Cancer

被引：1
作者：
Pinevich, A. A. [1 ]
Samoilovich, M. P. [1 ]
Shashkova, O. A. [1 ]
Vartanyan, N. L. [1 ]
Polysalov, V. N. [1 ]
Kiseleva, L. N. [1 ]
Kartashev, A. V. [1 ]
Aizenshtadt, A. A. [2 ]
Klimovich, V. B. [1 ]
机构：
[1] Minist Hlth Russian Federat, Russian Res Ctr Radiol & Surg Technol, St Petersburg, Russia
[2] Pokrovskii Stem Cell Bank, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 05期
关键词：
mesenchymal stromal cells; immunophenotype; breast cancer; REDUCED OXYGEN-TENSION; HUMAN ADIPOSE-TISSUE; STEM-CELL; BONE-MARROW; DIFFERENTIATION; EXPRESSION; PLASTICITY; CONTRIBUTE; HYPOXIA;
D O I：
10.1007/s10517-014-2640-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Mesenchymal stromal cells were isolated from the adipose tissue obtained during surgery for breast cancer and cultured under conditions of normal or low oxygen concentrations. In patients that had received a course of radiation and polychemotherapy prior to surgery, the proliferative potential of mesenchymal stromal cells was irreversibly disturbed. In patients receiving no therapy prior to surgery, the morphological, growth, phenotypic, and differentiation characteristics of mesenchymal stromal cells did not differ from the corresponding parameters of mesenchymal stromal cells from healthy donors. Culturing under hypoxic conditions increased adipogenic differentiation potencies of mesenchymal stromal cells from donors and patients.
引用
收藏
页码：666 / 672
页数：7
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