The smallest organocatalyst in highly enantioselective direct aldol reaction in wet solvent-free conditions

被引：29

作者：

Bhowmick, Sudipto ^{[1
]}

Kunte, Sunita S. ^{[2
]}

Bhowmick, Kartick C. ^{[1
]}

机构：

[1] Visva Bharati Univ, Dept Chem, Div Organ Synth, Santini Ketan 731235, W Bengal, India

[2] Natl Chem Lab, Analyt Sect, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 46期

关键词：

SMALL ORGANIC-MOLECULE; RECYCLABLE ORGANOCATALYST; CHIRAL CATALYSTS; WATER; PROLINE; EFFICIENT; ACCELERATION; ALDEHYDES; POLYMER; ACIDS;

D O I：

10.1039/c4ra02690j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic efficacy of the smallest organocatalyst, L-proline hydrazide, prepared from a cheaply available natural amino acid, such as L-proline, was studied for the direct asymmetric aldol reaction of various ketones with aromatic aldehydes at room temperature in the presence of several acid additives. A loading of 10 mol% of catalyst 1 and p-toluenesulphonic acid as an additive was employed in this reaction, and good yields (up to 99%) with high anti/syn diastereoselectivities (up to 95 : 5) and enantioselectivities (up to >99.9%) were achieved in aqueous media.

引用

页码：24311 / 24315

页数：5

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