Microginins 299-A and -B, leucine aminopeptidase inhibitors from the Cyanobacterium Microcystis aeruginosa (NIES-299)

被引：35

作者：

Ishida, K ^{[1
]}

Matsuda, H ^{[1
]}

Murakami, M ^{[1
]}

Yamaguchi, K ^{[1
]}

机构：

[1] UNIV TOKYO, GRAD SCH AGR LIFE SCI, MARINE BIOCHEM LAB, BUNKYO KU, TOKYO 113, JAPAN

来源：

TETRAHEDRON | 1997年 / 53卷 / 30期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4020(97)00684-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microginins 299-A (1) and -B (3) have been isolated from the cyanobacterium Microcystis aeruginosa (NIES-299). Their structures were determined by two-dimensional H-1-H-1 and H-1-C-13 NMR correlation experiments and confirmed by mass spectral and amino acid analyses. Their absolute stereochemistries were deducted by a combination of spectral and chemical studies. 1 and 2 inhibited leucine aminopeptidase with IC50's of 4.6 and 6.5 mu g/mL. respectively. (C) 1997 Elsevier Science Ltd.

引用

页码：10281 / 10288

页数：8

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