Open Targets: a platform for therapeutic target identification and validation

被引：300

作者：

Koscielny, Gautier ^{[1
,2
]}

An, Peter ^{[1
,3
]}

Carvalho-Silva, Denise ^{[1
,4
]}

Cham, Jennifer A. ^{[1
,4
]}

Fumis, Luca ^{[1
,4
]}

Gasparyan, Rippa ^{[1
,3
]}

Hasan, Samiul ^{[1
,2
]}

Karamanis, Nikiforos ^{[1
,4
]}

Maguire, Michael ^{[1
,4
]}

Papa, Eliseo ^{[1
,3
]}

Pierleoni, Andrea ^{[1
,4
]}

Pignatelli, Miguel ^{[1
,4
]}

Platt, Theo ^{[1
,3
]}

Rowland, Francis ^{[1
,4
]}

Wankar, Priyanka ^{[1
,3
]}

Bento, A. Patricia ^{[1
,4
]}

Burdett, Tony ^{[1
,4
]}

Fabregat, Antonio ^{[1
,4
]}

Forbes, Simon ^{[1
,5
]}

Gaulton, Anna ^{[1
,4
]}

Gonzalez, Cristina Yenyxe ^{[1
,4
]}

Hermjakob, Henning ^{[1
,4
,6
]}

Hersey, Anne ^{[1
,4
]}

Jupe, Steven ^{[1
,4
]}

Kafkas, Senay ^{[1
,4
]}

Keays, Maria ^{[1
,4
]}

Leroy, Catherine ^{[1
,4
]}

Lopez, Francisco-Javier ^{[1
,4
]}

Magarinos, Maria Paula ^{[1
,4
]}

Malone, James ^{[1
,4
]}

McEntyre, Johanna ^{[1
,4
]}

Fuentes, Alfonso Munoz-Pomer ^{[1
,4
]}

O'Donovan, Claire ^{[1
,4
]}

Papatheodorou, Irene ^{[1
,4
]}

Parkinson, Helen ^{[1
,4
]}

Palka, Barbara ^{[1
,4
]}

Paschall, Justin ^{[1
,4
]}

Petryszak, Robert ^{[1
,4
]}

Pratanwanich, Naruemon ^{[1
,4
]}

Sarntivijal, Sirarat ^{[1
,4
]}

Saunders, Gary ^{[1
,4
]}

Sidiropoulos, Konstantinos ^{[1
,4
]}

Smith, Thomas ^{[1
,4
]}

Sondka, Zbyslaw ^{[1
,5
]}

Stegle, Oliver ^{[1
,4
]}

Tang, Amy ^{[1
,4
]}

Turner, Edward ^{[1
,4
]}

Vaughan, Brendan ^{[1
,4
]}

Vrousgou, Olga ^{[1
,4
]}

Watkins, Xavier ^{[1
,4
]}

机构：

[1] Open Targets, Wellcome Genome Campus, Cambridge CB10 1SD, England

[2] GSK, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England

[3] Biogen, Cambridge, MA 02142 USA

[4] European Bioinformat Inst EMBL EBI, Wellcome Genome Campus, Cambridge CB10 1SD, England

[5] Wellcome Trust Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England

[6] Natl Ctr Prot Res, 38 Life Sci Pk Rd, Beijing 102206, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

关键词：

PHENOTYPE ONTOLOGY; DRUG-TARGET; DATABASE; UPDATE; DISEASE; ASSOCIATION; KNOWLEDGE; RESOURCE; CATALOG; GENES;

D O I：

10.1093/nar/gkw1055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target-and disease-centric workflows. The Open Targets Validation Platform is accessible at https:// www.targetvalidation.org.

引用

页码：D985 / D994

页数：10

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