Fabrication and characterization of 45S5 bioglass reinforced macroporous calcium silicate bioceramics

被引：32
作者：
Lin, Kaili [1 ]
Chang, Jiang [1 ]
Liu, Ziwei [1 ]
Zeng, Yi [1 ]
Shen, Ruxiang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China
来源：
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY | 2009年 / 29卷 / 14期
关键词：
Macroporous calcium silicate; Mechanical properties; Glass; Biomedical applications; Reinforcement; SIMULATED BODY-FLUIDS; APATITE FORMATION; IN-VITRO; CERAMICS; HYDROXYAPATITE; BEHAVIOR; BONE; BIOACTIVITY; IMPLANTS; COATINGS;
D O I：
10.1016/j.jeurceramsoc.2009.04.025
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Bioactive and degradable macroporous bioceramics play an important role in clinical applications. In the present study, 45S5 bioglass reinforced macroporous calcium silicate ceramics (45BG-reinforced MCSCs) were fabricated. The effect of bioglass additives on compressive strength and open porosity of the samples was investigated, and the bioactivity and degradability of the obtained reinforced samples were also evaluated. The 45S5 bioglass additive was found to be effective to increase the strength of the MCSCs by the liquid-phase sintering mechanism. The optimum amount of bioglass additives was 5 wt.% and the compressive strength of the reinforced samples was approximately 2 times higher as compared to the pure macroporous calcium silicate ceramics (MCSCs). The compressive strength of the reinforced samples with about 50% porosity reached 112.47 MPa, which was similar to those of the cortical bones. After soaking in simulated body fluid (SBF), hydroxycarbonate apatite (HCA) layer was formed on the surface of the 45BG-reinforced MCSCs. Furthermore, the degradation rate of the reinforced samples was just about one-third of those pure MCSCs. Our results indicated that degradable 45BG-reinforced MCSCs possess excellent mechanical strength and bioactivity, and may be used as bioactive and degradable biomaterials for hard tissue prosthetics or bone tissue engineering applications. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2937 / 2943
页数：7
相关论文
共 33 条
[1]   EVALUATION OF A BIODEGRADABLE CERAMIC [J].
CAMERON, HU ;
MACNAB, I ;
PILLIAR, RM .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1977, 11 (02) :179-186
[2]   Osteoconduction at porous hydroxyapatite with various pore configurations [J].
Chang, BS ;
Lee, CK ;
Hong, KS ;
Youn, HJ ;
Ryu, HS ;
Chung, SS ;
Park, KW .
BIOMATERIALS, 2000, 21 (12) :1291-1298
[3]   Morphological and structural study of pseudowollastonite implants in bone [J].
De Aza, P.N. ;
Luklinska, Z.B. ;
Martinez, A. ;
Anseau, M.R. ;
Guitian, F. ;
De Aza, S. ;
De Aza, S. .
Journal of Microscopy, 2000, 197 (01) :60-67
[4]  
DUCHEYNE P, 1987, J BIOMED MATER RES-A, V21, P219
[5]   Formation of surface reaction products on bioactive glass and their effects on the expression of the osteoblastic phenotype and the deposition of mineralized extracellular matrix [J].
ElGhannam, A ;
Ducheyne, P ;
Shapiro, IM .
BIOMATERIALS, 1997, 18 (04) :295-303
[6]  
Engin NO, 1999, J EUR CERAM SOC, V19, P2569
[7]  
FLATLEY TJ, 1983, CLIN ORTHOP RELAT R, P246
[8]   INFRARED STUDIES OF APATITES .1. VIBRATIONAL ASSIGNMENTS FOR CALCIUM, STRONTIUM, AND BARIUM HYDROXYAPATITES UTILIZING ISOTOPIC-SUBSTITUTION [J].
FOWLER, BO .
INORGANIC CHEMISTRY, 1974, 13 (01) :194-207
[9]   Processing and characterization of bioglass reinforced hydroxyapatite composites [J].
Goller, G ;
Demirkiran, H ;
Oktar, FN ;
Demirkesen, E .
CERAMICS INTERNATIONAL, 2003, 29 (06) :721-724
[10]   Preparation and characterization of novel bioactive dicalcium silicate ceramics [J].
Gou, ZR ;
Chang, J ;
Zhai, WY .
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2005, 25 (09) :1507-1514
1234