Hydrolysis and intramolecular transesterification of 3′-thioinosine 3′-S-phosphorothiolate triester

被引：0

作者：

Elzagheid, MI ^{[1
]}

Mäki, E ^{[1
]}

Kaukinen, U ^{[1
]}

Oivanen, M ^{[1
]}

Lönnberg, H ^{[1
]}

机构：

[1] Univ Turku, Dept Chem, FIN-20014 Turku, Finland

来源：

CHEMISTRY OF NUCLEIC ACID COMPONENTS | 1999年 / 2卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hydrolytic reactions of the dimethyl ester of 3'-deoxy-3'-thioinosine-3'-S-phosphorothiolate (1b) have been followed by HPLC. At pH > 3, only hydroxide-ion-catalyzed isomerization to the 2'-O-dimethyl phosphate takes place, whereas under more acidic conditions even hydrolysis to the 2'-O- and 3'-S-monomethyl phosphates was observed. Both reactions are acid-catalyzed at pH < 1. The mechanisms of the reactions are discussed in comparison with those of a corresponding RNA dimer analog (IspU, 2) and 3'-O-phosphate alkyl esters.

引用

页码：1 / 5

页数：5

共 9 条

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