The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004

被引：24

作者：

Bacher, Ulrike ^{[1
]}

Klyuchnikov, Evgeny ^{[1
,2
]}

Zabelina, Tatjana ^{[1
]}

Ottinger, Hellmut ^{[3
,4
]}

Beelen, Dietrich W. ^{[3
,4
]}

Schrezenmeier, Hubert ^{[3
,4
,5
]}

Ehninger, Gerhard ^{[3
,4
,6
]}

Mueller, Carlheinz ^{[3
,4
]}

Berger, Juergen ^{[7
]}

Suttorp, Meinolf ^{[8
]}

Kolb, Hans-Jochem ^{[9
]}

Kroeger, Nicolaus ^{[1
]}

Zander, Axel R. ^{[1
]}

机构：

[1] Univ Canc Ctr Hamburg UCCH, Interdisziplinare Klin Stammzelltransplantat, D-20246 Hamburg, Germany

[2] State Pavlovs Med Univ, Klin Stammzelltransplantat, St Petersburg, Russia

[3] Univ Klinikum Essen, DRST, KMT Klin, Ulm, Germany

[4] ZKRD, Ulm, Germany

[5] Univ Ulm, Inst Klin Transfus Med & Immungenet Ulm, Ulm, Germany

[6] Univ Klinikum Carl Gustav Carus Dresden, Med Klin & Poliklin 1, Dresden, Germany

[7] Univ Hamburg, Zentrum Expt Med, Inst Med Biometrie & Epidemiol, Hamburg, Germany

[8] Carl Gustav Carus Univ Dresden, Klin & Poliklin Kinder & Jugendmed, Dresden, Germany

[9] Univ Munich, Med Klin 3, Munich, Germany

来源：

ANNALS OF HEMATOLOGY | 2009年 / 88卷 / 12期

关键词：

Allogeneic stem cell transplantation (SCT); Chronic myeloid leukemia (CML); Dose-reduced conditioning (RIC); Myeloablative conditioning; German Registry of Stem Cell Transplantation (DRST); CHRONIC MYELOGENOUS LEUKEMIA; BONE-MARROW-TRANSPLANTATION; IMMUNOGENETIC DONOR SEARCH; DISEASE-FREE-SURVIVAL; REDUCED-INTENSITY; IMATINIB MESYLATE; BCR-ABL; HEMATOLOGIC MALIGNANCIES; FOLLOW-UP; THERAPY;

D O I：

10.1007/s00277-009-0737-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related (n = 767) or unrelated donors (n = 938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004. Myeloablative conditioning was performed in 724/871 cases (83%), dose-reduced conditioning in 147/871 (17%). Annual transplantations were decreasing from 357 to 98 (28%) in the period of study, but the proportion of advanced cases was increasing from 32% (112/346) to 53% (50/94) of all SCTs. Stage of disease, intervals from diagnosis, and patients' age were independent prognostic parameters, while peripheral stem cells and unrelated transplantation seemed equal to bone marrow/related transplantation. This study demonstrates that allo-SCT still has an important role in advanced CML, which emphasizes the need for optimized transplantation strategies for these high-risk patients.

引用

页码：1237 / 1247

页数：11

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