An aryne triggered ring-opening fluorination of cyclic thioethers with potassium fluoride

被引：40
|
作者：
Fan, Rong [1 ]
Liu, Binbin [1 ]
Zheng, Tianyu [1 ]
Xu, Kun [2 ]
Tan, Chen [1 ]
Zeng, Tianlong [1 ]
Su, Shuaisong [1 ]
Tan, Jiajing [1 ]
机构：
[1] Beijing Univ Chem Technol, Dept Organ Chem, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing 100029, Peoples R China
[2] Nanyang Normal Univ, Coll Chem & Pharmaceut Engn, Nanyang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 51期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
ALIPHATIC CARBOXYLIC-ACIDS; ENANTIOSELECTIVE FLUORINATION; DECARBOXYLATIVE FLUORINATION; TRIARYLSULFONIUM SALTS; STEVENS REARRANGEMENT; N-ARYLATION; METAL; CHEMISTRY; CATALYSIS; SULFIDES;
D O I：
10.1039/c8cc03766c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report an aryne triggered ring-opening fluorination protocol of a great variety of saturated sulfur heterocycles. A key factor for the success is the identification of a suitable mediator. Compared to previous methods, this transition-metal free protocol employs low-cost potassium fluoride as the fluorine source. The operational simplicity and mild reaction conditions allow for the rapid synthesis of a wide range of aliphatic fluoride compounds in good yields.
引用
收藏
页码：7081 / 7084
页数：4
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