Tumor organoid models in precision medicine and investigating cancer-stromal interactions

被引:83
作者
Xu, Ren [1 ,2 ]
Zhou, Xiaotao [2 ]
Wang, Shike [2 ]
Trinkle, Christine [3 ]
机构
[1] Univ Kentucky, Dept Pharmacol & Nutr Sci, Lexington, KY 40536 USA
[2] Univ Kentucky, Markey Canc Ctr, Lexington, KY 40508 USA
[3] Univ Kentucky, Dept Mech Engn, Lexington, KY 40506 USA
关键词
Three-dimensional tissue culture; Patient-derived organoid; Personalized treatment; Drug screening; Tumor microenvironment; Extracellular matrix; DOMAIN RECEPTOR 1; EXTRACELLULAR-MATRIX; EPITHELIAL-CELLS; UP-REGULATION; HUMAN COLON; MACROPHAGES; MICROENVIRONMENT; PROGRESSION; INVASION; CULTURE;
D O I
10.1016/j.pharmthera.2020.107668
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tumor development and progression require chemical and mechanical cues derived from cellular and noncellular components in the tumor microenvironment, including the extracellular matrix (ECM), cancer-associated fibroblasts (CAR), endothelial cells, and immune cells. Therefore, it is crucial to develop tissue culture models that can mimic in vivo cancer cell-ECM and cancer-stromal cell interactions. Three-dimensional (3D) tumor culture models have been widely utilized to study cancer development and progression. A recent advance in 3D culture is the development of patient-derived tumor organoid (PDO) models from primary human cancer tissue. PDOs maintain the heterogeneity of the primary tumor, which makes them more relevant for identifying therapeutic targets and verifying drug response. Other significant advances include development of 3D coculture assays to investigate cell-cell interactions and tissue/organ morphogenesis, and microfluidic technology that can be integrated into 3D culture to mimic vasculatu re and blood flow. These advances offer spatial and temporal insights into cancer cell-stromal interactions and represent novel techniques to study tumor progression and drug response. Here, we summarize the recent progress in 3D culture and tumor organoid models, and discuss future directions and the potential of utilizing these models to study cancer-stromal interactions and direct personalized treatment. (C) 2020 Elsevier Inc. All rights reserved.
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页数:10
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