Isoforms of hyaluronidases can be a predictor of a prostate cancer of good prognosis

被引：4
作者：
de Sa, Vanessa K. [1 ]
Canavez, Flavio C. [2 ]
Silva, Iran A. [1 ]
Srougi, Miguel [1 ]
Leite, Katia R. M. [1 ,2 ]
机构：
[1] Univ Sao Paulo, Lab Med Invest LIM55, Sch Med, Dept Urol, Sao Paulo, Brazil
[2] Genoa Biotechnol, Sao Paulo, Brazil
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2009年 / 27卷 / 04期
关键词：
Hyaluronidases; Hyaluronan; Alternative splicing; Prostate cancer; Prognosis; EXPRESSION; GROWTH; ACID;
D O I：
10.1016/j.urolonc.2008.04.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction: Hyaluronidases (HAases) are enzymes related to cancer progression. Isoforms of HAases have been described as products of alternative splicing responsible for differences in enzyme activity. The heterogeneity of HAase expression has been identified in tumors and could be related to the differences in their biological behavior. Methods: Thirty-seven patients subjected to radical prostatectomy for prostate cancer were divided into 2 groups for the analyses: Low (<= 6-18) and high (>= 7-19) Gleason score and tumor behavior; recurrence 15 and nonrecurrence 22, mean follow-up 52.6 months. Conclusion: A profile of HAase related to low Gleason score and non-tumor recurrence was characterized by expression of HYAL3-v1, HYAL1-v3, and HYAL3-v2. More studies should be made in order to confirm with larger series. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：377 / 381
页数：5
相关论文
共 22 条
  • [1] [Anonymous], 2007, CANC FACTS FIG
  • [2] Expression of HYAL2 mRNA, hyaluronan and hyaluronidase in B-cell non-Hodgkin lymphoma:: Relationship with tumor aggressiveness
    Bertrand, P
    Courel, MN
    Maingonnat, C
    Jardin, F
    Tilly, H
    Bastard, C
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2005, 113 (02) : 207 - 212
  • [3] Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis
    Chao, Kinlin L.
    Muthukumar, Lavanya
    Herzberg, Osnat
    [J]. BIOCHEMISTRY, 2007, 46 (23) : 6911 - 6920
  • [4] Hyaluronan: Fundamental principles and applications in cancer
    Delpech, B
    Girard, N
    Bertrand, P
    Courel, MN
    Chauzy, C
    Delpech, A
    [J]. JOURNAL OF INTERNAL MEDICINE, 1997, 242 (01) : 41 - 48
  • [5] A validation of two preoperative nomograms predicting recurrence following radical prostatectomy in a cohort of European men
    Graefen, M
    Karakiewicz, PI
    Cagiannos, I
    Hammerer, PG
    Haese, A
    Palisaar, J
    Fernandez, S
    Noldus, J
    Erbersdobler, A
    Huland, H
    Scardino, PT
    Kattan, MW
    [J]. UROLOGIC ONCOLOGY, 2002, 7 (04): : 141 - 146
  • [6] Sodium hyaluronate regulating angiogenesis during Achilles tendon healing
    Halici, M
    Karaoglu, S
    Canoz, O
    Kabak, S
    Baktir, A
    [J]. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2004, 12 (06) : 562 - 567
  • [7] CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and-2
    Harada, Hosami
    Takahashi, Masaaki
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (08) : 5597 - 5607
  • [8] Herrlich P, 2000, ANN NY ACAD SCI, V910, P106
  • [9] HOBARTH K, 1992, EUR UROL, V21, P206
  • [10] Differential protein expression in anatomical zones of the prostate
    Lexander, H
    Franzén, B
    Hirschberg, D
    Becker, S
    Hellström, M
    Bergman, T
    Jörnvall, H
    Auer, G
    Egevad, L
    [J]. PROTEOMICS, 2005, 5 (10) : 2570 - 2576
123