Signal integration by JNK and p38 MAPK pathways in cancer development

被引:2085
作者
Wagner, Erwin F. [1 ]
Nebreda, Angel R. [1 ]
机构
[1] Ctr Nacl Invest Oncol, Madrid 28029, Spain
关键词
ACTIVATED PROTEIN-KINASE; JUN NH2-TERMINAL KINASE-1; SKIN TUMOR-DEVELOPMENT; EMBRYONIC STEM-CELLS; N-TERMINAL KINASES; C-JUN; TNF-ALPHA; TRANSDUCTION PATHWAY; CARCINOMA-CELLS; GENE-EXPRESSION;
D O I
10.1038/nrc2694
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members function in a cell context-specific and cell type-specific manner to integrate signals that affect proliferation, differentiation, survival and migration. Consistent with the importance of these events in tumorigenesis, JNK and p38 MAPK signalling is associated with cancers in humans and mice. Studies in mouse models have been essential to better understand how these MAPKs control cancer development, and these models are expected to provide new strategies for the design of improved therapeutic approaches. In this Review we highlight the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers.
引用
收藏
页码:537 / 549
页数:13
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