The extracellular matrix in epithelial ovarian cancer - a piece of a puzzle

被引：108
作者：
Cho, Angela [1 ,2 ]
Howell, Viive M. [2 ,3 ]
Colvin, Emily K. [2 ,3 ]
机构：
[1] Univ Technol Sydney, Sch Med & Mol Biosci, Sydney, NSW 2007, Australia
[2] Kolling Inst, Bill Walsh Translat Canc Res Lab, St Leonards, NSW, Australia
[3] Univ Sydney, Sydney Med Sch Northern, Sydney, NSW 2006, Australia
来源：
FRONTIERS IN ONCOLOGY | 2015年 / 5卷
关键词：
extracellular matrix; ovarian cancer; proteases; collagen; proteoglycan; HEPARAN-SULFATE PROTEOGLYCANS; LEUCINE-RICH PROTEOGLYCANS; GROWTH-FACTOR RECEPTOR; HYALURONAN SYNTHASE EXPRESSION; DIFFERENTIAL GENE-EXPRESSION; OXIDASE G473A POLYMORPHISM; ELASTIN-DERIVED PEPTIDES; LYSYL OXIDASE; TISSUE INHIBITOR; IN-VIVO;
D O I：
10.3389/fonc.2015.00245
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epithelial ovarian cancer is the fifth leading cause of cancer-related deaths in women and the most lethal gynecological malignancy. Extracellular matrix (ECM) is an integral component of both the normal and tumor microenvironment. ECM composition varies between tissues and is crucial for maintaining normal function and homeostasis. Dysregulation and aberrant deposition or loss of ECM components is implicated in ovarian cancer progression. The mechanisms by which tumor cells induce ECM remodeling to promote a malignant phenotype are yet to be elucidated. A thorough understanding of the role of the ECM in ovarian cancer is needed for the development of effective biomarkers and new therapies.
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页数：16
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