Effects of REM sleep deprivation on sensorimotor gating and startle habituation in rats: Role of social isolation in early development

被引：8
作者：
Chang, Hsin-An [1 ]
Liu, Yia-Ping [1 ,2 ]
Tung, Che-Se [3 ]
Chang, Chuan-Chia [1 ]
Tzeng, Nian-Sheng [1 ,4 ]
Huang, San-Yuan [1 ]
机构：
[1] Natl Def Med Ctr, Triserv Gen Hosp, Dept Psychiat, Taipei 114, Taiwan
[2] Natl Def Med Ctr, Dept Physiol & Biophys, Taipei 114, Taiwan
[3] Cheng Hsin Gen Hosp, Div Med Res & Educ, Taipei, Taiwan
[4] Natl Def Med Ctr, Student Counseling Ctr, Taipei 114, Taiwan
来源：
NEUROSCIENCE LETTERS | 2014年 / 575卷
关键词：
Isolation rearing; Prepulse inhibition; REM sleep deprivation; Schizophrenia; Startle habituation; CEREBRAL-BLOOD-FLOW; PREPULSE INHIBITION; 1ST-EPISODE SCHIZOPHRENIA; REPEATED STRESS; DEFICITS; CONSEQUENCES; REVERSAL; BEHAVIOR; REFLEX;
D O I：
10.1016/j.neulet.2014.05.032
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study examined the role of rapid eye movement (REM) sleep on sensorimotor gating function in a developmentally rodent model of schizophrenic-spectrum disorders. Startle magnitude, prepulse inhibition (PPI) and startle habituation in an acoustic startle test were measured after 72-h of REM sleep deprivation (REMSD) in 14-week-old rats that were reared in one of the following conditions: control social interaction, 2-week isolation, and continuous isolation, since weaning. The results showed that REMSD significantly inhibited rats' PPI in socially controlled rats, and rats in two isolation groups appeared less sensitive to REMSD. After REMSD, startle habituation was significantly reduced in continuous-isolated rats but not in 2-week-isolated rats. These data indicate that REM sleep is essential for PPI; REMSD inhibits startle habituation in rats with continuous social isolation. In addition, social interaction, in early life or for the whole life, functions differently to the sensorimotor gating. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：63 / 67
页数：5
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