Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase (Statins) Suppress Differentiation and Reduce LPS/IFNγ-Induced Cytokine Production in Human Monocyte/Macrophage Culture

被引：3

作者：

Ruleva, N. Yu ^{[1
]}

Radyukhina, N., V ^{[1
]}

Zubkova, E. S. ^{[1
]}

Filatova, A. Yu ^{[1
]}

Aref'eva, T., I ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Natl Med Res Ctr Cardiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 170卷 / 02期

关键词：

inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins); monocyte; macrophages; differentiation; activation; apoptosis;

D O I：

10.1007/s10517-020-05042-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We examined the effects of 72-h exposure to atorvastatin and rosuvastatin in concentrations of 2-10 nM on the cytokine expression in LPS/IFN gamma-activated monocyte/macrophages derived from peripheral blood monocytes of healthy donors by culturing in the presence of GM-CSF. Pretreatment with statins was found to inhibit cytokine production in monocytes/macrophages after activation, while the level of cytokine mRNA in cells did not decrease. The number of cells containing active caspase-3 decreased in the culture. Culturing of monocytes/macrophages with statins was accompanied by changes in cell morphology and deceleration of cell growth. Cellular effects of "lipophilic" atorvastastin were observed at lower concentration compared to "hydrophilic" rosuvastatin.

引用

页码：236 / 240

页数：5

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