Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)

被引：66

作者：

Qiu, Lingyu ^{[1
,2
]}

Jia, Kun ^{[1
,2
,3
]}

Huang, Lirong ^{[1
,2
,3
]}

Liao, Xinjun ^{[1
,2
,3
]}

Guo, Xinchun ^{[4
]}

Lu, Huiqiang ^{[1
,2
,3
]}

机构：

[1] Jiangxi Engn Lab Zebrafish Modeling & Drug Screen, Jian, Jiangxi, Peoples R China

[2] Jiangxi Key Lab Dev Biol Organs, Jian, Jiangxi, Peoples R China

[3] Jinggangshan Univ, Coll Life Sci, Ctr Dev Biol, Jian, Jiangxi, Peoples R China

[4] Gannan Normal Univ, Sch Geog & Environm Engn, Ganzhou, Jiangxi, Peoples R China

来源：

CHEMOSPHERE | 2019年 / 232卷

基金：

中国国家自然科学基金;

关键词：

Tricyclazole; Hepatotoxicity; Oxidative stress; Metabolism disorder; Zebrafish; CONSTITUTIVE ANDROSTANE RECEPTOR; DEVELOPMENTAL TOXICITY; LIVER HYPERTROPHY; MOUSE-LIVER; MODEL; INVOLVEMENT; ACTIVATION; PESTICIDES; TOXICOLOGY; APOPTOSIS;

D O I：

10.1016/j.chemosphere.2019.05.159

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：171 / 179

页数：9

共 49 条

[41] Importance of Endocytic Pathways in Liver Function and Disease [J].

Schroederand, Barbara ;

McNiven, Mark A. .

COMPREHENSIVE PHYSIOLOGY, 2014, 4 (04) :1403-1417

[42] Foxa3 (hepatocyte nuclear factor 3γ) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast [J].

Shen, W ;

Scearce, LM ;

Brestelli, JE ;

Sund, NJ ;

Kaestner, KH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (46) :42812-42817

[43] Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism [J].

Sinha, Rohit A. ;

Singh, Brijesh K. ;

Yen, Paul M. .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2014, 25 (10) :538-545

[44] Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides [J].

Tamura, Kei ;

Inoue, Kaoru ;

Takahashi, Miwa ;

Matsuo, Saori ;

Irie, Kaoru ;

Kodama, Yukio ;

Garno, Toshie ;

Ozawa, Shogo ;

Yoshida, Midori .

FOOD AND CHEMICAL TOXICOLOGY, 2015, 78 :86-95

[45] Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides [J].

Tamura, Kei ;

Inoue, Kaoru ;

Takahashi, Miwa ;

Matsuo, Saori ;

Irie, Kaoru ;

Kodama, Yukio ;

Ozawa, Shogo ;

Nishikawa, Akiyoshi ;

Yoshida, Midori .

TOXICOLOGY LETTERS, 2013, 221 (01) :47-56

[46] Wnt/β-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3 [J].

Tao, Guo-Zhong ;

Lehwald, Nadja ;

Jang, Kyu Yun ;

Baek, Joy ;

Xu, Baohui ;

Omary, M. Bishr ;

Sylvester, Karl G. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (24) :17214-17224

[47] Herbal hepatotoxicity and WHO global introspection method [J].

Teschke, Rolf ;

Eickhoff, Axel ;

Wolff, Albrecht ;

Frenzel, Christian ;

Schulze, Johannes .

ANNALS OF HEPATOLOGY, 2013, 12 (01) :11-21

[48] Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity [J].

Verstraelen, Sandra ;

Peers, Bernard ;

Maho, Walid ;

Hollanders, Karen ;

Remy, Sylvie ;

Berckmans, Pascale ;

Covaci, Adrian ;

Witters, Hilda .

JOURNAL OF APPLIED TOXICOLOGY, 2016, 36 (09) :1194-1206

[49] Zebrafish as model organisms for studying drug-induced liver injury [J].

Vliegenthart, A. D. Bastiaan ;

Tucker, Carl S. ;

Del Pozo, Jorge ;

Dear, James W. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 78 (06) :1217-1227

← 1 2 3 4 5 →