Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)

被引：64

作者：

Qiu, Lingyu ^{[1
,2
]}

Jia, Kun ^{[1
,2
,3
]}

Huang, Lirong ^{[1
,2
,3
]}

Liao, Xinjun ^{[1
,2
,3
]}

Guo, Xinchun ^{[4
]}

Lu, Huiqiang ^{[1
,2
,3
]}

机构：

[1] Jiangxi Engn Lab Zebrafish Modeling & Drug Screen, Jian, Jiangxi, Peoples R China

[2] Jiangxi Key Lab Dev Biol Organs, Jian, Jiangxi, Peoples R China

[3] Jinggangshan Univ, Coll Life Sci, Ctr Dev Biol, Jian, Jiangxi, Peoples R China

[4] Gannan Normal Univ, Sch Geog & Environm Engn, Ganzhou, Jiangxi, Peoples R China

来源：

CHEMOSPHERE | 2019年 / 232卷

基金：

中国国家自然科学基金;

关键词：

Tricyclazole; Hepatotoxicity; Oxidative stress; Metabolism disorder; Zebrafish; CONSTITUTIVE ANDROSTANE RECEPTOR; DEVELOPMENTAL TOXICITY; LIVER HYPERTROPHY; MOUSE-LIVER; MODEL; INVOLVEMENT; ACTIVATION; PESTICIDES; TOXICOLOGY; APOPTOSIS;

D O I：

10.1016/j.chemosphere.2019.05.159

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：171 / 179

页数：9

共 49 条

[1] Liver glucose metabolism in humans [J].

Adeva-Andany, Maria M. ;

Perez-Felpete, Noemi ;

Fernandez-Fernandez, Carlos ;

Donapetry-Garcia, Cristobal ;

Pazos-Garcia, Cristina .

BIOSCIENCE REPORTS, 2016, 36

[2]

[Anonymous], 2020, The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification

[3] Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery [J].

Barros, T. P. ;

Alderton, W. K. ;

Reynolds, H. M. ;

Roach, A. G. ;

Berghmans, S. .

BRITISH JOURNAL OF PHARMACOLOGY, 2008, 154 (07) :1400-1413

[4] Optimality in the zonation of ammonia detoxification in rodent liver [J].

Bartl, Martin ;

Pfaff, Michael ;

Ghallab, Ahmed ;

Driesch, Dominik ;

Henkel, Sebastian G. ;

Hengstler, Jan G. ;

Schuster, Stefan ;

Kaleta, Christoph ;

Gebhardt, Rolf ;

Zellmer, Sebastian ;

Li, Pu .

ARCHIVES OF TOXICOLOGY, 2015, 89 (11) :2069-2078

[5] Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio [J].

Bui-Nguyen, Tri M. ;

Baer, Christine E. ;

Lewis, John A. ;

Yang, Dongren ;

Lein, Pamela J. ;

Jackson, David A. .

BMC GENOMICS, 2015, 16

[6] Review article: herbal and dietary supplement hepatotoxicity [J].

Bunchorntavakul, C. ;

Reddy, K. R. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 37 (01) :3-17

[7] Developmental toxicity of the fungicide ziram in zebrafish (Danio rerio) [J].

Cao, Fangjie ;

Souders, Christopher L., II ;

Li, Pengfei ;

Adamovsky, Ondrej ;

Pang, Sen ;

Qiu, Lihong ;

Martyniuk, Christopher J. .

CHEMOSPHERE, 2019, 214 :303-313

[8] Exogenous Thioredoxin Prevents Ethanol-Induced Oxidative Damage and Apoptosis in Mouse Liver [J].

Cohen, Jessica I. ;

Roychowdhury, Sanjoy ;

DiBello, Patricia M. ;

Jacobsen, Donald W. ;

Nagy, Laura E. .

HEPATOLOGY, 2009, 49 (05) :1709-1717

[9] 1,2,3-Triazole-Heme Interactions in Cytochrome P450: Functionally Competent Triazole-Water-Heme Complexes [J].

Conner, Kip P. ;

Vennam, Preethi ;

Woods, Caleb M. ;

Krzyaniak, Matthew D. ;

Bowman, Michael K. ;

Atkins, William M. .

BIOCHEMISTRY, 2012, 51 (32) :6441-6457

[10] Earthworms, pesticides and sustainable agriculture: a review [J].

Datta, Shivika ;

Singh, Joginder ;

Singh, Sharanpreet ;

Singh, Jaswinder .

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2016, 23 (09) :8227-8243

← 1 2 3 4 5 →