The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study

被引：17
作者：
Crema, M. D. [1 ,2 ]
Cibere, J. [3 ,4 ]
Sayre, E. C. [4 ]
Roemer, F. W. [1 ,5 ]
Wong, H. [4 ,6 ]
Thorne, A. [6 ]
Singer, J. [6 ]
Esdaile, J. M. [3 ]
Marra, M. D. [1 ]
Kopec, J. A. [3 ]
Nicolaou, S. [3 ]
Guermazi, A. [1 ]
机构：
[1] Boston Univ, Sch Med, Quantitat Imaging Ctr, Dept Radiol, Boston, MA 02118 USA
[2] Hosp Coracao HCor & Teleimagem, Dept Radiol, Sao Paulo, Brazil
[3] Univ British Columbia, Dept Med, Vancouver, BC, Canada
[4] Arthrit Res Ctr Canada, Richmond, BC, Canada
[5] Univ Erlangen Nurnberg, Dept Radiol, Erlangen, Germany
[6] Univ British Columbia, Sch Populat Publ Hlth, Vancouver, BC V5Z 1M9, Canada
来源：
OSTEOARTHRITIS AND CARTILAGE | 2014年 / 22卷 / 04期
基金：
加拿大健康研究院;
关键词：
Cartilage; Knee; Osteoarthritis; Subchondral bone; Magnetic resonance imaging; BONE-MARROW LESIONS; ARTICULAR-CARTILAGE; EDEMA PATTERN; JOINT; COMPARTMENT; DAMAGE; MORPHOLOGY; ATTRITION; DISEASE; MODEL;
D O I：
10.1016/j.joca.2014.01.006
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Purpose: To assess the association between subchondral sclerosis detected at baseline with MRI and cartilage loss over time in the same region of the knee in a cohort of subjects with knee pain. Methods: 163 subjects with knee pain participated in a longitudinal study to assess knee osteoarthritis progression (KOAP). Subjects received baseline knee radiographs as well as baseline and 3-year follow-up MRI examinations. Baseline subchondral sclerosis and bone marrow lesions (BMLs) were scored semiquantitatively on MRI in each region from 0 to 3. Cartilage morphology at baseline and follow-up was scored semiquantitatively from 0 to 4. The association between baseline subchondral sclerosis and cartilage loss in the same region of the knee was evaluated using logistic regression, adjusting the results for age, gender, body mass index, and the presence of concomitant BMLs. Results: The prevalence of subchondral sclerosis detected by MRI in the regions of the knee varied between 1.6% (trochlea) and 17% (medial tibia). The occurrence of cartilage loss over time in regions varied between 6% (lateral tibia) and 13.1% (medial femur). The prevalence of radiographically-detected subchondral sclerosis in compartments varied from 2.9% (patellofemoral) to 14.2% (medial tibiofemoral). In logistic regression models, there were no significant associations between baseline subchondral sclerosis detected by MRI and cartilage loss in the same region of the knee. Conclusion: Baseline subchondral sclerosis as detected by MRI did not increase the risk of cartilage loss over time. (C) 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：540 / 546
页数：7
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