Mycobacterium alvei (ω-1)-methoxy mycolic acids: Absolute stereochemistry and synthesis

被引：2
作者：
Alhuwaymil, Zamzam S. [1 ]
Al-araj, Intisar Q. M. [2 ,5 ]
Al Dulayymi, Ahmad R. [1 ]
Jones, Alison [1 ]
Gates, Paul J. [3 ]
Valero-Guillen, Pedro L. [4 ]
Baird, Mark S. [2 ]
Al Dulayymi, Juma'a R. [1 ]
机构：
[1] Bangor Univ, Sch Nat Sci, Bangor LL57 2UW, Gwynedd, Wales
[2] Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales
[3] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
[4] Univ Murcia, Fac Med, Inst Murciano Invest Biosanitaria IMIB, Dept Genet & Microbiol, Murcia, Spain
[5] Univ Mosul, Coll Educ Pure Sci, Dept Chem, Mosul, Iraq
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 2020年 / 233卷
关键词：
Mycobacterium; Alvei; Mycolic acid; (omega-1)-Methoxy; Synthesis; SUR LA STRUCTURE; DACIDES MYCOLIQUES; SINGLE ENANTIOMERS; CORD FACTORS; BIOSYNTHESIS; ALPHA; RHODOCOCCUS; DIMYCOLATE; INFECTION; SMEGMATIS;
D O I：
10.1016/j.chemphyslip.2020.104977
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cells of Mycobacterium alvei are known to contain a unique set of mycolic acids with a (omega-1)-methoxy group; although the various enzymes in the biosynthesis of other types of mycolic acid have been widely studied, the biosynthetic route to this substituent is unclear. We now define the stereochemistry of the (omega-1)-methoxy fragment as R, and describe the synthesis of a major R-(omega-1)-methoxy-mycolic acid and its sugar esters, and of two natural M. alvei diene mycolic acids.
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页数：14
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