Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

被引：310

作者：

Caudle, Kelly E. ^{[1
]}

Klein, Teri E. ^{[2
]}

Hoffman, James M. ^{[1
]}

Mueller, Daniel J. ^{[3
,4
]}

Whirl-Carrillo, Michelle ^{[2
]}

Gong, Li ^{[2
]}

McDonagh, Ellen M. ^{[2
]}

Sangkuhl, Katrin ^{[2
]}

Thorn, Caroline F. ^{[2
]}

Schwab, Matthias ^{[5
,6
]}

Agundez, Jose A. G. ^{[7
]}

Freimuth, Robert R. ^{[8
]}

Huser, Vojtech ^{[9
]}

Lee, Ming Ta Michael ^{[10
,11
,12
]}

Iwuchukwu, Otito F. ^{[13
]}

Crews, Kristine R. ^{[1
]}

Scott, Stuart A. ^{[14
]}

Wadelius, Mia ^{[15
]}

Swen, Jesse J. ^{[16
]}

Tyndale, Rachel F. ^{[3
,4
]}

Stein, C. Michael ^{[13
,17
]}

Roden, Dan ^{[13
,17
]}

Relling, Mary V. ^{[1
]}

Williams, Marc S. ^{[18
]}

Johnson, Samuel G. ^{[19
,20
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

[2] Stanford Univ, Dept Genet, Palo Alto, CA 94304 USA

[3] Ctr Addict & Mental Hlth, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany

[6] Univ Hosp, Inst Expt & Clin Pharmacol & Toxicol, Dept Clin Pharmacol, Tubingen, Germany

[7] Univ Extremadura, Dept Pharmacol, Caceres, Spain

[8] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[9] NIH, Lab Informat Dev, Ctr Clin, Bethesda, MD 20892 USA

[10] RIKEN Ctr Integrat Med Sci, Lab Int Alliance Genom Res, Yokohama, Kanagawa, Japan

[11] Acad Sinica, Inst Biomed Sci, Natl Ctr Genome Med, Taipei, Taiwan

[12] China Med Univ, Sch Chinese Med, Taichung, Taiwan

[13] Vanderbilt Univ, Dept Med, Nashville, TN USA

[14] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

[15] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[16] Leiden Univ, Med Ctr, Dept Clin Pharm & Toxicol, Leiden, Netherlands

[17] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA

[18] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA

[19] Univ Colorado, Dept Clin Pharm, Skaggs Sch Pharm & Pharmaceut Sci, Denver, CO 80202 USA

[20] Kaiser Permanente Colorado, Clin Pharm Serv, Denver, CO USA

来源：

CURRENT DRUG METABOLISM | 2014年 / 15卷 / 02期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

Clinical practice guideline; guideline; pharmacogenetics; pharmacogenomics; THIOPURINE METHYLTRANSFERASE GENOTYPE; HLA-B GENOTYPE; CYP2C19; GENOTYPE; THERAPY;

D O I：

10.2174/1389200215666140130124910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic test results could be used to optimize drug therapy. CPIC has focused initially on well-known examples of pharmacogenomic associations that have been implemented in selected clinical settings, publishing nine to date. Each CPIC guideline adheres to a standardized format and includes a standard system for grading levels of evidence linking genotypes to phenotypes and assigning a level of strength to each prescribing recommendation. CPIC guidelines contain the necessary information to help clinicians translate patient-specific diplotypes for each gene into clinical phenotypes or drug dosing groups. This paper reviews the development process of the CPIC guidelines and compares this process to the Institute of Medicine's Standards for Developing Trustworthy Clinical Practice Guidelines.

引用

页码：209 / 217

页数：9

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