Paediatrician's guide to epigenetics

被引：1

作者：

Byrne, Lauren ^{[1
]}

Drake, Amanda Jane ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Univ British Heart Fdn Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Royal Hosp Sick Children, Dept Paediat Endocrinol, Edinburgh, Midlothian, Scotland

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2019年 / 104卷 / 03期

关键词：

DNA METHYLATION; GENES; EXPOSURE; FAMINE; BIRTH;

D O I：

10.1136/archdischild-2018-316054

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Epigenetic regulation of gene expression is critical for normal development. Dysregulation of the epigenome can lead to the development and progression of a number of diseases relevant to paediatricians, including disorders of genomic imprinting and malignancies. It has long been recognised that early life events have implications for future disease risk, and epigenetic modifications may play a role in this, although further high-quality research is needed to better understand the underlying mechanisms. Research in the field of epigenetics will contribute to a greater understanding of growth, development and disease; however, paediatricians need to be able to interpret such research critically, in order to use the potential advances brought about through epigenetic studies while appreciating their limitations.

引用

页码：297 / 301

页数：5

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