Imipenem versus piperacillin/tazobactam for empiric treatment of neutropenic fever in adults

被引：11
作者：
Roohullah, A. [1 ]
Moniwa, A. [1 ]
Wood, C. [1 ,2 ]
Humble, M. [3 ,4 ]
Balm, M. [4 ]
Carter, J. [1 ,3 ]
Weinkove, R. [1 ,3 ]
机构：
[1] Capital & Coast Dist Hlth Board, Wellington Blood & Canc Ctr, Wellington 6242, New Zealand
[2] Univ Otago Wellington, Malaghan Inst Med Res, Wellington, New Zealand
[3] Univ Otago Wellington, Dept Pathol & Mol Med, Wellington, New Zealand
[4] Capital & Coast Dist Hlth Board, Microbiol Lab, Wellington 6242, New Zealand
来源：
INTERNAL MEDICINE JOURNAL | 2013年 / 43卷 / 10期
关键词：
neutropenia; sepsis; imipenem; piperacillin; tazobactam; FEBRILE NEUTROPENIA; CANCER-PATIENTS; ANTIMICROBIAL THERAPY; TAZOBACTAM; CHEMOTHERAPY; MONOTHERAPY; GUIDELINES; MANAGEMENT; CEFEPIME; SOCIETY;
D O I：
10.1111/imj.12226
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Australian guidelines for neutropenic fever recommend piperacillin/tazobactam (PIP-TAZ) or cefepime for first-line empiric treatment of neutropenic fever. We compared outcomes among haematology patients before and after changing our first-line neutropenic fever treatment from imipenem to PIP-TAZ. Forty-five patients received imipenem and 60 PIP-TAZ. Despite a higher rate of antibiotic modification in the PIP-TAZ cohort, treatment success and time to defervescence were similar, with a trend towards fewer Clostridium difficile infections in the PIP-TAZ cohort.
引用
收藏
页码：1151 / 1154
页数：4
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