MIF in autoimmunity and novel therapeutic approaches

被引：77
作者：
Stosic-Grujicic, Stanislava [2 ]
Stojanovic, Ivana [2 ]
Nicoletti, Ferdinando [1 ]
机构：
[1] Univ Catania, I-95124 Catania, Italy
[2] Inst Biol Res Dr Sinisa Stankovic, Belgrade, Serbia
来源：
AUTOIMMUNITY REVIEWS | 2009年 / 8卷 / 03期
关键词：
MIF; Autoimmunity; Inflammation; MIGRATION INHIBITORY FACTOR; FACTOR GENE POLYMORPHISM; SERUM-LEVELS; ARTHRITIS; MICE; BLOCKADE; GLOMERULONEPHRITIS; INFLAMMATION; ASSOCIATION; DESTRUCTION;
D O I：
10.1016/j.autrev.2008.07.037
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophage migration inhibitory factor (MIF) is a multipotent cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune disorders. Since anti-cytokine therapy is considered to be a promising therapeutic strategy, selective targeting of MIF with either anti-MIF antibody or specific chemical MIF inhibitors might offer new therapeutic avenues for these disorders. Considering the unique relationship between MIF and glucocorticoids, therapeutic antagonism of MIF could also represent an effective approach for steroid-sparing therapies in patients with refractory autoimmune diseases. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：244 / 249
页数：6
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