MIF in autoimmunity and novel therapeutic approaches

被引：77
作者：
Stosic-Grujicic, Stanislava [2 ]
Stojanovic, Ivana [2 ]
Nicoletti, Ferdinando [1 ]
机构：
[1] Univ Catania, I-95124 Catania, Italy
[2] Inst Biol Res Dr Sinisa Stankovic, Belgrade, Serbia
来源：
AUTOIMMUNITY REVIEWS | 2009年 / 8卷 / 03期
关键词：
MIF; Autoimmunity; Inflammation; MIGRATION INHIBITORY FACTOR; FACTOR GENE POLYMORPHISM; SERUM-LEVELS; ARTHRITIS; MICE; BLOCKADE; GLOMERULONEPHRITIS; INFLAMMATION; ASSOCIATION; DESTRUCTION;
D O I：
10.1016/j.autrev.2008.07.037
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophage migration inhibitory factor (MIF) is a multipotent cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune disorders. Since anti-cytokine therapy is considered to be a promising therapeutic strategy, selective targeting of MIF with either anti-MIF antibody or specific chemical MIF inhibitors might offer new therapeutic avenues for these disorders. Considering the unique relationship between MIF and glucocorticoids, therapeutic antagonism of MIF could also represent an effective approach for steroid-sparing therapies in patients with refractory autoimmune diseases. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：244 / 249
页数：6
相关论文
共 40 条
  • [1] Amoli MM, 2002, J RHEUMATOL, V29, P1671
  • [2] CYTOKINES IN THE CENTRAL-NERVOUS-SYSTEM OF MICE DURING CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
    BAKER, D
    ONEILL, JK
    TURK, JL
    [J]. CELLULAR IMMUNOLOGY, 1991, 134 (02) : 505 - 510
  • [3] Relationship between serum levels of macrophage migration inhibitory factor and the activity of antineutrophil cytoplasmic antibody-associated vasculitides
    Becker, H
    Maaser, C
    Mickholz, E
    Dyong, A
    Domschke, W
    Gaubitz, M
    [J]. CLINICAL RHEUMATOLOGY, 2006, 25 (03) : 368 - 372
  • [4] Association of macrophage migration inhibitory factor-173C allele polymorphism with steroid resistance in children with nephrotic syndrome
    Berdeli, A
    Mir, S
    Ozkayin, N
    Serdaroglu, E
    Tabel, Y
    Cura, A
    [J]. PEDIATRIC NEPHROLOGY, 2005, 20 (11) : 1566 - 1571
  • [5] Macrophage migration inhibitory factor and development of type-1 diabetes in non-obese diabetic mice
    Bojunga, J
    Kusterer, K
    Bacher, M
    Kurek, R
    Usadel, KH
    Renneberg, H
    [J]. CYTOKINE, 2003, 21 (04) : 179 - 186
  • [6] Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity
    Cheng, Kai Fan
    Al-Abed, Yousef
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (13) : 3376 - 3379
  • [7] Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor
    Crichlow, Gregg V.
    Cheng, Kai Fan
    Dabideen, Darrin
    Ochani, Mahendar
    Aljabari, Bayan
    Pavlov, Valentin A.
    Miller, Edmund J.
    Lolis, Elias
    Al-Abed, Yousef
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (32) : 23089 - 23095
  • [8] Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes
    Cvetkovic, I
    Al-Abed, Y
    Miljkovic, D
    Maksimovic-Ivanic, D
    Roth, J
    Bacher, M
    Lan, HY
    Nicoletti, F
    Stosic-Grujicic, S
    [J]. ENDOCRINOLOGY, 2005, 146 (07) : 2942 - 2951
  • [9] Neutralization of macrophage migration inhibitory factor - novel approach for the treatment of immunoinflammatory disorders
    Cvetkovic, Ivana
    Stosic-Grujicic, Stanislava
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2006, 6 (10) : 1527 - 1534
  • [10] Macrophage migration inhibitory factor (MIF)-173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease
    Dambacher, Julia
    Staudinger, Tanja
    Seiderer, Julia
    Sisic, Zeljka
    Schnitzler, Fabian
    Pfennig, Simone
    Hofbauer, Katrin
    Konrad, Astrid
    Tillack, Cornelia
    Otte, Jan-Michel
    Diebold, Joachim
    Goeke, Burkhard
    Ochsenkuehn, Thomas
    Lohse, Peter
    Brand, Stephan
    [J]. INFLAMMATORY BOWEL DISEASES, 2007, 13 (01) : 71 - 82
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